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Comparison of outcomes between haploidentical and matched related donors for chronic myelomonocytic leukemia: A multicenter real-world study

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机构： [1]National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China [2]Department of Hematology, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong Province, China [3]Department of Hematology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China [4]Department of Hematology, Xiangya Hospital of Central South University, Changsha, China [5]Department of Hematology, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China [6]Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China [7]Department of Hematology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China [8]Hematology Section, Cancer Center, The First Hospital of Jilin University, Changchun, China [9]Hematology Department, The 960th Hospital of the People's Liberation Army (PLA) Joint Logistics Support Force, Jinan, China [10]Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China [11]Department of Hematology, Bone Marrow Transplant Center, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China [12]Department of Hematology, Changhai Hospital, The Naval Medical University, Shanghai, China [13]Department of Hematology, Zhujiang Hospital of Southern Medical University, Guangzhou, China [14]Department of Hematology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China [15]Department of Hematology, Peking University First Hospital, Beijing, China [16]Xinqiao Hospital, The Third Military Medical University, Chongqing, China [17]Department of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China [18]Department of Hematology, Jiangsu Province Hospital, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China [19]Department of Hematology, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China [20]Department of Hematology, School of First Affiliated Hospital of Shandong First Medical University, Shandong Province Qianfoshan Hospital, Jinan, China [21]Department of Hematology, West China Hospital, Sichuan University, Chengdu, China [22]Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China [23]Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China [24]Department of Hematology, The Second Affiliated Hospital (Tangdu Hospital) of Air Force Medical University, Xi'an, China [25]Department of Hematology, Western Theater General Hospital of the People's Liberation Army of China, Chengdu, China [26]Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, China [27]Department of Hematology, The Third Xiangya Hospital of Central South University, Changsha, China [28]Department of Hematology, Qilu Hospital, Shandong University, Jinan, China

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关键词： chronic myelomonocytic leukemia haploidentical donors matched related donors outcomes

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Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative strategy for patients with chronic myelomonocytic leukemia (CMML). However, few reports have investigated the outcomes of patients receiving haploidentical HSCT. To this end, we included 117 patients with haploidentical donors (HID) and 75 patients with matched related donors (MRD) from 28 centers across China to explore the prognostic impact of different transplantation modalities. We found no significant difference between these two groups in terms of event-free survival (EFS, p = .211), overall survival (OS, p = .503), cumulative incidence of relapse (CIR, p = .076) or non-relapse mortality (NRM, p = .794). The predominance of peripheral blood (PB) graft source over bone marrow and PB since 2020 may have contributed to the worse outcomes in the MRD group. Moreover, CMML-specific prognostic scoring system (CPSS) lower-risk patients benefited more from the HID modality with superior EFS (p = .006). Multivariate analysis indicated that advanced age (p = .013), anemia at diagnosis (p = .010), and donor relationship (parent-to-child, p = .013) were independently associated with worse EFS in the HID group. Our data suggested that HID was comparable to MRD in CMML. However, under certain conditions, such as CPSS lower-risk ones, HID was preferred.© 2025 UICC.

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出版当年[2025]版：

大类 | 2 区医学

小类 | 2 区肿瘤学

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大类 | 2 区医学

小类 | 2 区肿瘤学

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Q1 ONCOLOGY

最新[2024]版：

Q1 ONCOLOGY

影响因子： 4.7 最新[2024版] 5.9 最新五年平均 4.7 出版当年[2024版] 0 出版当年五年平均 4.7 出版前一年[2024版]

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第一作者机构： [1]National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China

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Comparison of outcomes between haploidentical and matched related donors for chronic myelomonocytic leukemia: A multicenter real-world study

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