机构：[1]Translational Chinese Medicine Key Laboratory of Sichuan Province, Sichuan Institute for Translational Chinese Medicine, Sichuan Academy of Chinese Medicine Sciences, Chengdu 610041, China.[2]Sichuan Institute for Translational Chinese Medicine, Chengdu 610041, China.[3]West China Hospital, Sichuan University, Chengdu 610041, China.四川大学华西医院[4]School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Tetrahydrocurcumin (THC), a curcumin derivative, shows potential in oncology and neurology. It regulates NF-κB, reduces inflammation, promotes cancer cell apoptosis, inhibits tumor angiogenesis, and enhances antioxidants, aiding in treating inflammation-related cancers. In neurology, THC's anti-inflammatory and antioxidant properties protect neurons, reduce neuroinflammation, and support autophagy for cellular debris clearance, with its blood-brain barrier penetration offering a neuroprotective edge. Research on THC's therapeutic application must focus on improving delivery and bioavailability and confirming its clinical safety and efficacy.
基金：
The work is supported by the Foundation of National Natural Science Foundation of
China (82404939), the National Natural Science Foundation of Sichuan (2024NSFSC56101834). the
Science and Technology Development Fund (005/2023/SKL) and the State Key Laboratory of Quality
Research in Chinese Medicine, University of Macau (No.SKL-QRCM-OP24014).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类|3 区生物学
小类|3 区生化与分子生物学3 区化学：综合
最新[2025]版：
大类|3 区生物学
小类|3 区生化与分子生物学3 区化学：综合
第一作者：
第一作者机构：[1]Translational Chinese Medicine Key Laboratory of Sichuan Province, Sichuan Institute for Translational Chinese Medicine, Sichuan Academy of Chinese Medicine Sciences, Chengdu 610041, China.[2]Sichuan Institute for Translational Chinese Medicine, Chengdu 610041, China.
通讯作者：
通讯机构：[1]Translational Chinese Medicine Key Laboratory of Sichuan Province, Sichuan Institute for Translational Chinese Medicine, Sichuan Academy of Chinese Medicine Sciences, Chengdu 610041, China.[2]Sichuan Institute for Translational Chinese Medicine, Chengdu 610041, China.
推荐引用方式(GB/T 7714)：
Zeng Anqi,Quan Yunyun,Tao Hongxia,et al.The Role of Tetrahydrocurcumin in Tumor and Neurodegenerative Diseases Through Anti-Inflammatory Effects[J].International Journal Of Molecular Sciences.2025,26(8):doi:10.3390/ijms26083561.
APA：
Zeng Anqi,Quan Yunyun,Tao Hongxia,Dai Ying,Song Linjiang&Zhao Junning.(2025).The Role of Tetrahydrocurcumin in Tumor and Neurodegenerative Diseases Through Anti-Inflammatory Effects.International Journal Of Molecular Sciences,26,(8)
MLA：
Zeng Anqi,et al."The Role of Tetrahydrocurcumin in Tumor and Neurodegenerative Diseases Through Anti-Inflammatory Effects".International Journal Of Molecular Sciences 26..8(2025)
