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Saponins isolated from Radix polygalae extent lifespan by modulating complement C3 and gut microbiota.

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资源类型：
Pubmed体系：
作者：
Zeng Wu[1,5] ; Wu An Guo[2] ; Zhou Xiao-Gang[2] ; Khan Imran[1] ; Zhang Rui Long[1] ; Lo Hang Hong[1] ; Qu Li Qun[1] ; Song Lin Lin[1] ; Yun Xiao Yun[1] ; Wang Hui Miao[1] ; Chen Juan[3] ; Ng Jerome P L[1] ; Ren Fang[3] ; Yuan Si Yu[3] ; Yu Lu[1,2] ; Tang Yong[1] ; Huang Guo Xin[1] ; Wong Vincent Kam Wai[1] ; Chung Sookja Kim[4] ; Mok Simon Wing Fai[4] ; Qin Da Lian[2] ; Sun Hua Lin[1] ; Liu Liang[1] ; Hsiao W L Wendy[1] ; Law Betty Yuen Kwan[1] ;
机构： [1]State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau [2]Sichuan Key Medical Laboratory of New Drug Discovery and Drug Ability Evaluation, Key Laboratory of Medical Electrophysiology of Ministry of Education, School of Pharmacy, Southwest Medical University, Luzhou, China [3]The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China [4]Department of Medicine, Macau University of Science and Technology, Taipa, Macau [5]Department of Center for Neuro-metabolism and Regeneration Research, Bioland Laboratory, Guangzhou, China
出处：
DOI： 10.1016/j.phrs.2021.105697
ISSN：

关键词： Complement system Aging Gut microbiota C elegans Neurodegenerative disease

摘要：
With the increase in human lifespan, population aging is one of the major problems worldwide. Aging is an irreversible progressive process that affects humans via multiple factors including genetic, immunity, cellular oxidation and inflammation. Progressive neuroinflammation contributes to aging, cognitive malfunction, and neurodegenerative diseases. However, precise mechanisms or drugs targeting age-related neuroinflammation and cognitive impairment remain un-elucidated. Traditional herbal plants have been prescribed in many Asian countries for anti-aging and the modulation of aging-related symptoms. In general, herbal plants' efficacy is attributed to their safety and polypharmacological potency via the systemic manipulation of the body system. Radix polygalae (RP) is a herbal plant prescribed for anti-aging and the relief of age-related symptoms; however, its active components and biological functions remained un-elucidated. In this study, an active methanol fraction of RP containing 17 RP saponins (RPS), was identified. RPS attenuates the elevated C3 complement protein in aged mice to a level comparable to the young control mice. The active RPS also restates the aging gut microbiota by enhancing beneficial bacteria and suppressing harmful bacteria. In addition, RPS treatment improve spatial reference memory in aged mice, with the attenuation of multiple molecular markers related to neuroinflammation and aging. Finally, the RPS improves the behavior and extends the lifespan of C. elegans, confirming the herbal plant's anti-aging ability. In conclusion, through the mouse and C. elegas models, we have identified the beneficial RPS that can modulate the aging process, gut microbiota diversity and rectify several aging-related phenotypes.Copyright © 2021 Elsevier Ltd. All rights reserved.

基金：
This work was supported by grants from the Macao Science and Technology Development Fund, Macau, China (Project Code: 0060/ 2018/A2 and 0036/ 2018/AFJ), Foshan Medicine Dengfeng Project, China (2019-2021), the National Natural Science Foundation of China, China (Grant No. 81903829), and the Science and Technology Planning Project of Sichuan Province, China (Grant no. 2018JY0474).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 2 区 医学
小类 | 2 区 药学
最新[2023]版：
大类 | 2 区 医学
小类 | 1 区 药学
第一作者：
第一作者机构： [1]State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau [5]Department of Center for Neuro-metabolism and Regeneration Research, Bioland Laboratory, Guangzhou, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Zeng Wu,Wu An Guo,Zhou Xiao-Gang,et al.Saponins isolated from Radix polygalae extent lifespan by modulating complement C3 and gut microbiota.[J].Pharmacological research.2021,170:105697.doi:10.1016/j.phrs.2021.105697.
APA：
Zeng Wu,Wu An Guo,Zhou Xiao-Gang,Khan Imran,Zhang Rui Long...&Law Betty Yuen Kwan.(2021).Saponins isolated from Radix polygalae extent lifespan by modulating complement C3 and gut microbiota..Pharmacological research,170,
MLA：
Zeng Wu,et al."Saponins isolated from Radix polygalae extent lifespan by modulating complement C3 and gut microbiota.".Pharmacological research 170.(2021):105697

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