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Role of Gold Nanorods Functionalized by Nucleic Acid Nanostructures Carrying Doxorubicin in Synergistic Anti-Cancer Therapy

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收录情况： ◇ 统计源期刊 ◇ 卓越：梯队期刊

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机构： [1]Department of Stomatology, the First Medical Centre, Chinese PLA General Hospital, Beijing 100853, China. [2]State Key Laboratory of Oral Disease, National Clinical Research Center for Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu 610064, Sichuan, China. [3]NHC Key Laboratory of Comparative Medicine, National Human Diseases Animal Model Resource Center, Beijing Key Laboratory for Animal Models of Emerging and Reemerging Infectious Diseases, National Center of Technology Innovation for Animal Model, Institute of Medical Laboratory Animal Science, CAMS &PUMC, Beijing 100021, China.

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关键词： Gold Nanorods Synergistic therapy Nanomaterials Anti-tumor therapy

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Cancer remains a significant global health challenge, necessitating the development of effective treatment approaches. Developing synergistic therapy can provide a highly promising strategy for anti-cancer treatment through combining the benefits of various mechanisms.In this study, we developed a synergistic strategy for chemo-photothermal therapy by constructing nanocomposites using gold nanorods (GNRs) and tetrahedral framework nucleic acids (tFNA) loaded with the anti-tumor drug doxorubicin (DOX).Our in vitro studies have systematically clarified the anti-cancer behaviors of tFNA-DOX@GNR nanocomposites, characterized by their enhanced cellular uptake and proficient lysosomal escape capabilities. It was found that the key role of tFNA-DOX@GNR nanocomposites in tumor ablation is primarily due to their capacity to induce cytotoxicity in tumor cells via a photothermal effect, which generates instantaneous high temperatures. This mechanism introduces various responses in tumor cells, facilitated by the thermal effect and the integrated chemotherapeutic action of DOX. These reactions include the induction of endoplasmic reticulum stress, characterized by elevated reactive oxygen species levels, the promotion of apoptotic cell death, and the suppression of tumor cell proliferation.This work exhibits the potential of synergistic therapy utilizing nanocomposites for cancer treatment and offers a promising avenue for future therapeutic strategies.Copyright © 2025 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.

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出版当年[2025]版：

大类 | 4 区医学

小类 | 4 区环境科学 4 区公共卫生、环境卫生与职业卫生

最新[2025]版：

大类 | 4 区医学

小类 | 4 区环境科学 4 区公共卫生、环境卫生与职业卫生

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第一作者机构： [1]Department of Stomatology, the First Medical Centre, Chinese PLA General Hospital, Beijing 100853, China.

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