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Peroxidase-Mimetic Iron Silicate Nanosheets Coordinated with Indocyanine Green for Enhanced Anti-Tumor Therapy

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机构： [1]Department of Laboratory Medicine/Clinical Laboratory Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. [2]Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China. [3]Sichuan Clinical Research Center for Laboratory Medicine, Chengdu, Sichuan, 610041, China. [4]Division of Liver Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. [5]College of Chemistry and Chemical Engineering, and Key Laboratory of Photonic and Electronic Bandgap Materials, Ministry of Education, Harbin Normal University, Harbin, Heilongjiang, 150025, China. [6]Center for High Altitude·Medicine West China Hospital Sichuan University Chengdu, Sichuan 610041, China [7]College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan, Shandong, 250014, China.

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关键词： anti-tumor therapy FeSi nanosheet indocyanine green nanozyme peroxidase

摘要：

The versatile element composition and multifunctional properties of biodegradable silicates have attracted significant attention in cancer therapeutics. However, their application as nanozymes is often limited by suboptimal catalytic efficiency and insufficient intratumoral retention. In this study, the hydrothermal synthesis of iron silicate (FeSi) nanosheets are reported exhibiting exceptional peroxidase (POD)-like activity (136.7 U mg-1), outperforming most reported iron-based nanozymes. Density functional theory calculations revealed that the introduction of Si into the catalyst enhances H2O2 adsorption and dissociation of Fe sites, leading to superior POD performance. Furthermore, the FeSi nanosheets are modified with Indocyanine Green (ICG) to facilitate targeted aggregation-potentiated therapy. The integration of ICG improved tumor penetration and retention of the FeSi nanosheets, significantly increasing their reactive oxygen species production and bolstering therapeutic efficacy.© 2024 Wiley‐VCH GmbH.

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出版当年[2023]版：

大类 | 2 区

医学

小类 | 2 区工程：生物医学 2 区材料科学：生物材料 2 区纳米科技

最新[2023]版：

大类 | 2 区

医学

小类 | 2 区工程：生物医学 2 区材料科学：生物材料 2 区纳米科技

第一作者：

第一作者机构： [1]Department of Laboratory Medicine/Clinical Laboratory Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. [2]Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China. [3]Sichuan Clinical Research Center for Laboratory Medicine, Chengdu, Sichuan, 610041, China.

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通讯作者：

通讯机构： [1]Department of Laboratory Medicine/Clinical Laboratory Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. [2]Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China. [3]Sichuan Clinical Research Center for Laboratory Medicine, Chengdu, Sichuan, 610041, China. [6]Center for High Altitude·Medicine West China Hospital Sichuan University Chengdu, Sichuan 610041, China [7]College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan, Shandong, 250014, China.

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Peroxidase-Mimetic Iron Silicate Nanosheets Coordinated with Indocyanine Green for Enhanced Anti-Tumor Therapy

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