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Clinical Application of 3D-Printed Custom Hemipelvic Prostheses With Negative Poisson's Ratio Porous Structures in Reconstruction After Resection of Pelvic Malignant Tumors

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机构: [1]Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China. [2]Model Worker and Craftsman Talent Innovation Workshop of Sichuan Province, Sichuan University, Chengdu, China. [3]Operating Room, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, China. [4]National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China. [5]Provincial Engineering Research Center for Biomaterials Genome of Sichuan, Sichuan University, Chengdu, China.
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关键词: 3D-printed hemipelvectomy osteosarcoma prostheses

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Pelvic bone tumor resection and reconstruction present significant challenges due to complex anatomy and weight-bearing demands. 3D-printed hemipelvic prostheses, incorporating customized osteotomy guides and porous structures, offer a promising solution for enhancing osseointegration. This study evaluates the long-term outcomes of 3D-printed custom hemipelvic reconstruction with a focus on the integration of auxetic biomaterials with a negative Poisson's ratio to optimize mechanical properties.A retrospective analysis was conducted on 12 patients with primary pelvic malignancies who underwent reconstruction using 3D-printed hemipelvic prostheses between January 2018 and May 2023. Follow-up duration was 48 months (range, 29-64 months) Oncological, functional, surgical, pain control, and radiographic outcomes were assessed.At the latest follow-up, 8 patients (66.7%) were disease-free, 3 (25%) had disease progression, and 1 (8.3%) died from metastatic complications. Functional outcomes improved significantly, with the MSTS-93 score increasing from 15 (range, 12-17) to 26 (range, 21-29). Pain scores decreased from 5 (range, 4-7) to 1 (range, 0-2). The median surgical duration was 270 min (range, 150-560 min), with intraoperative blood loss averaging 3200 mL (range, 1900-6300 mL). Complications included poor wound healing in 2 patients (16.7%), managed with VAC drainage. No mechanical failures, loosening, or fractures occurred. Accurate osteotomy, prosthesis implantation, and screw fixation were achieved. Successful osseointegration was observed in all cases, with no signs of bone absorption or osteolysis.3D-printed custom hemipelvic prostheses with auxetic biomaterials offer an effective solution for pelvic reconstruction, providing promising oncological, functional, and radiographic outcomes. These findings support the use of 3D printing in complex pelvic defect reconstruction, optimizing both osteointegration and mechanical strength.© 2025 The Author(s). Orthopaedic Surgery published by Tianjin Hospital and John Wiley & Sons Australia, Ltd.

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出版当年[2025]版:
大类 | 4 区 医学
小类 | 4 区 骨科
最新[2025]版:
大类 | 4 区 医学
小类 | 4 区 骨科
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第一作者机构: [1]Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China. [2]Model Worker and Craftsman Talent Innovation Workshop of Sichuan Province, Sichuan University, Chengdu, China.
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通讯机构: [1]Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China. [2]Model Worker and Craftsman Talent Innovation Workshop of Sichuan Province, Sichuan University, Chengdu, China. [4]National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China. [5]Provincial Engineering Research Center for Biomaterials Genome of Sichuan, Sichuan University, Chengdu, China.
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