机构：[1]Analytical & Testing Center, Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610065, China.四川大学华西医院[2]College of Medical Technology and Engineering, Henan University of Science and Technology, 263 Kaiyuan Avenue, Luoyang 471023, China.[3]Advanced Composite Research Group (ACRG), School of Mechanical and Aerospace Engineering, Queens University Belfast, Belfast BT9 5AH, United Kingdom.[4]Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang 110016, China.[5]School of Materials Science and Physics, China University of Mining and Technology, Xuzhou 221116, China.
Osteosarcoma is a challenging bone disease which is commonly associated with critically sized bone defects and cancer recurrence. Here, we designed and developed a multifunctional, hierarchical structured bone scaffold which can meet the demanding requirements for osteosarcoma management. The 3D printed Ti6Al4V scaffold with hydrothermally induced TiO2/TiP coating can offer a unique photothermal conversion property for in vitro bone cancer ablation. The scaffold is also infused with drug-laden gelatin/hydroxyapatite nanocomposite, which provides the ideal porous structure for cell adhesion/bone ingrowth and promotes bone regeneration. The scaffold has been thoroughly characterized by SEM/EDX, TEM, XPS, XRD, TGA, and UV-vis, and its in vitro bone cancer ablation efficiency has been validated using MG-63 cells. The hybrid scaffold showed excellent biocompatibility, and its osteointegration function has been demonstrated using an animal model.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|2 区化学
小类|2 区生化研究方法2 区化学综合2 区有机化学3 区生化与分子生物学
最新[2023]版：
大类|2 区化学
小类|2 区生化研究方法2 区有机化学3 区生化与分子生物学3 区化学：综合
第一作者：
第一作者机构：[1]Analytical & Testing Center, Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610065, China.[2]College of Medical Technology and Engineering, Henan University of Science and Technology, 263 Kaiyuan Avenue, Luoyang 471023, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Cai Bianyun,Huang Leizhen,Wang Jingcheng,et al.3D Printed Multifunctional Ti6Al4V-Based Hybrid Scaffold for the Management of Osteosarcoma.[J].Bioconjugate chemistry.2021,doi:10.1021/acs.bioconjchem.1c00367.
APA：
Cai Bianyun,Huang Leizhen,Wang Jingcheng,Sun Dan,Zhu Ce...&Zhang Li.(2021).3D Printed Multifunctional Ti6Al4V-Based Hybrid Scaffold for the Management of Osteosarcoma..Bioconjugate chemistry,,
MLA：
Cai Bianyun,et al."3D Printed Multifunctional Ti6Al4V-Based Hybrid Scaffold for the Management of Osteosarcoma.".Bioconjugate chemistry .(2021)
