机构：[1]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, P.R. China.四川大学华西医院[2]Shiley Eye Center and Institute for Genomic Medicine, University of California, San Diego, La Jolla, California 92093, USA[3]Department of NanoEngineering, University of California, San Diego, La Jolla, California 92093, USA[4]School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710062, P.R. China[5]Biomaterials and Tissue Engineering Center, University of California, San Diego, La Jolla, California 92093, USA.[6]Veterans Administration Healthcare System, San Diego, California 92093, USA.
Rationally designed nanoparticles that can bind toxins show great promise for detoxification. However, the conventional intravenous administration of nanoparticles for detoxification often leads to nanoparticle accumulation in the liver, posing a risk of secondary poisoning especially in liver-failure patients. Here we present a liver-inspired three-dimensional (3D) detoxification device. This device is created by 3D printing of designer hydrogels with functional polydiacetylene nanoparticles installed in the hydrogel matrix. The nanoparticles can attract, capture and sense toxins, while the 3D matrix with a modified liver lobule microstructure allows toxins to be trapped efficiently. Our results show that the toxin solution completely loses its virulence after treatment using this biomimetic detoxification device. This work provides a proof-of-concept of detoxification by a 3D-printed biomimetic nanocomposite construct in hydrogel, and could lead to the development of alternative detoxification platforms.
基金：
Grants (EB012597, EB017876 and EY021374) from
the National Institute of Biomedical Imaging and Bioengineering and a Grant (CMMI-
1120795) from the US National Science Foundation to S.C and K.Z.; M.G. and Y.W.
appreciated the support from the National Natural Science Foundation (81201785), the
National Science and Technology Major Project (2013ZX09301-304-008) and 863 Program
(2014AA020509, 2012AA021004). The UCSD Neuroscience Microscopy Shared
Facility was supported by Grant P30 (NS047101).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|2 区综合性期刊
小类|2 区综合性期刊
最新[2023]版：
大类|1 区综合性期刊
小类|1 区综合性期刊
第一作者：
第一作者机构：[1]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, P.R. China.[2]Shiley Eye Center and Institute for Genomic Medicine, University of California, San Diego, La Jolla, California 92093, USA
共同第一作者：
通讯作者：
通讯机构：[1]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, P.R. China.[2]Shiley Eye Center and Institute for Genomic Medicine, University of California, San Diego, La Jolla, California 92093, USA[3]Department of NanoEngineering, University of California, San Diego, La Jolla, California 92093, USA[5]Biomaterials and Tissue Engineering Center, University of California, San Diego, La Jolla, California 92093, USA.
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