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The Biology and Regulation of Spermatogonial Stem Cells in the Niche

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机构： [1]School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, SAR, China. [2]School of Biomedical Sciences Core Laboratory, Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, PR, China. [3]Sichuan University-The Chinese University of Hong Kong Joint Laboratory for Reproductive Medicine, West China Second University Hospital, Chengdu, PR, China.

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关键词： Intercellular communication Spermatogonial stem cell Male germline stem cell Microenvironment Niche

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Spermatogenesis, the process responsible for the daily production of millions of sperm, originates from spermatogonial stem cells (SSCs). Dysregulation of spermatogenesis is a major contributing factor to male infertility. Additionally, cryopreservation of SSCs followed by transplantation is a viable approach to restore spermatogenesis after sterilizing treatments such as chemotherapy and radiotherapy for cancer treatment. Therefore, investigating the biology and regulatory mechanisms involved in maintaining SSCs will provide valuable insights into the etiology of male fertility disorders and inform clinical strategies for fertility preservation and restoration. In this chapter, we will review the origin of SSCs, their biological and functional properties, and the various types of cells that contribute to the SSC niche. Additionally, we will discuss the regulation of SSC self-renewal and differentiation by niche factors, cell-cell and cell-extracellular matrix interactions, intrinsic gene regulation, and emerging intercellular communication mechanisms.© 2025. The Author(s), under exclusive license to Springer Nature Switzerland AG.

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第一作者机构： [1]School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, SAR, China.

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通讯机构： [1]School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, SAR, China. [2]School of Biomedical Sciences Core Laboratory, Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, PR, China. [3]Sichuan University-The Chinese University of Hong Kong Joint Laboratory for Reproductive Medicine, West China Second University Hospital, Chengdu, PR, China.

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