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Lung-specific metastasis: the coevolution of tumor cells and lung microenvironment

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机构: [1]Breast Disease Center and Institute for Breast Health Medicine, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. [2]Institute of Breast Health Medicine, West China Hospital, Sichuan University Chengdu, Sichuan, 610041, China. [3]Department of Medical Oncology, West China Hospital, Sichuan University, Cancer Center, Chengdu, Sichuan, 610041, China. [4]Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
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关键词: Reciprocal Tumor-Lung Metastatic Symbiosis (RTLMS) Lung-specific metastasis Coevolution Premetastatic niche Tumor colonization Dormancy Reawakening

摘要:
The vast majority of cancer-related deaths are attributed to metastasis. The lung, being a common site for cancer metastasis, is highly prone to being a target for multiple cancer types and causes a heavy disease burden. Accumulating evidence has demonstrated that tumor metastasis necessitates continuous interactions between tumor cells and distant metastatic niches. Nevertheless, a comprehensive elucidation of the underlying mechanisms governing lung-specific metastasis still poses a formidable challenge. In this review, we depict the lung susceptibility and the molecular profiles of tumors with the potential for lung metastasis. Under the conceptual framework of "Reciprocal Tumor-Lung Metastatic Symbiosis" (RTLMS), we mechanistically delineate the bidirectional regulatory dynamics and coevolutionary adaptation between tumor cells and distal pulmonary niches during lung-specific metastasis, including the induction of pre-metastatic-niches, positive responses of the lung, tumor colonization, dormancy, and reawakening. An enhanced understanding of the latest mechanisms is essential for developing targeted strategies to counteract lung-specific metastasis.© 2025. The Author(s).

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出版当年[2025]版:
大类 | 1 区 医学
小类 | 1 区 生化与分子生物学 1 区 肿瘤学
最新[2025]版:
大类 | 1 区 医学
小类 | 1 区 生化与分子生物学 1 区 肿瘤学
第一作者:
第一作者机构: [1]Breast Disease Center and Institute for Breast Health Medicine, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
通讯作者:
通讯机构: [3]Department of Medical Oncology, West China Hospital, Sichuan University, Cancer Center, Chengdu, Sichuan, 610041, China. [4]Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
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