Background Studies on sex-related differences in post-lung cancer surgery symptoms are limited. Understanding these differences may provide insights into patient recovery. Therefore, we investigated sex-related differences in these symptoms and their underlying associated factors. Methods We included patients aged >= 18 years undergoing surgery for lung cancer from a multicenter cohort study (CN-PRO-Lung 1) that focused on postoperative lung cancer symptoms trajectories. On a daily assessment schedule, we evaluated patients' symptoms and their impact on functioning from the day before surgery until discharge using the MD Anderson Symptom Inventory-Lung Cancer module. We evaluated sex-related differences in symptom scores over time and identified influencing factors using linear mixed models. Results Of 372 eligible patients (196 men and 176 women;) symptoms were milder in men than in women for pain (estimate = 0.427, P = 0.021), fatigue (estimate = 1.071, P < 0.001), shortness of breath (estimate = 0.431, P = 0.021), lack of appetite (estimate = 0.728, P < 0.001), dry mouth (estimate = 0.438, P = 0.015), and constipation (estimate = 0.887, P < 0.001) during postoperative hospitalization (median: 7 days). Pain scores decreased over time in both sexes (estimate = -0.440 in men, P < 0.001; -0.510 in women, P < 0.001), while different factors were associated with increased pain in each group. In men, higher American Society of Anesthesiologists (ASA) classification (estimate = 0.430, P = 0.035), advanced pTNM stage (estimate = 0.550, P = 0.007), and having more than one chest drain (estimate = 0.690, P = 0.001) were associated with greater pain. In women, systematic lymph node dissection was associated with increased pain (estimate = 0.700, P = 0.033). Conclusions Women reported a higher symptom burden than men in the early postoperative period after lung cancer surgery. Key factors associated with worse postoperative pain include higher ASA classification, advanced pTNM stage, and more than one chest tube in men and systematic lymph node dissection in women. Trial registration number NCT03341377
基金:
This work was supported by the National Key R&D Plan for Intergovernmental Cooperation, the Ministry of Science and Technology of China (grant number 2022YFE0133100) and the Natural Science Foundation of Sichuan Province (grant number 2023NSFSC1047).
第一作者机构:[1]Univ Elect Sci & Technol China, Sichuan Cancer Hosp & Inst, Sichuan Clin Res Ctr Canc, Sichuan Canc Ctr,Dept Thorac Surg, 55 Sec 4,South Renmin Rd, Chengdu 610041, Peoples R China
共同第一作者:
通讯作者:
通讯机构:[1]Univ Elect Sci & Technol China, Sichuan Cancer Hosp & Inst, Sichuan Clin Res Ctr Canc, Sichuan Canc Ctr,Dept Thorac Surg, 55 Sec 4,South Renmin Rd, Chengdu 610041, Peoples R China[2]Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China[3]Chongqing Med Univ, Sch Publ Hlth, Chongqing, Peoples R China
推荐引用方式(GB/T 7714):
Liao Jia,Hu Xiaoqun,Wei Xing,et al.Sex-related differences in postoperative patient-reported outcomes among lung cancer patients: a multicenter cohort study[J].BMC CANCER.2025,25(1):doi:10.1186/s12885-025-14191-z.
APA:
Liao, Jia,Hu, Xiaoqun,Wei, Xing,Dai, Wei,Yu, Hongfan...&Liu, Xiaoqin.(2025).Sex-related differences in postoperative patient-reported outcomes among lung cancer patients: a multicenter cohort study.BMC CANCER,25,(1)
MLA:
Liao, Jia,et al."Sex-related differences in postoperative patient-reported outcomes among lung cancer patients: a multicenter cohort study".BMC CANCER 25..1(2025)