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The influence and association of blood on transfer catheter and vaginal microbiota on pregnancy outcomes in frozen-embryo transfer cycles

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机构: [1]State Key Laboratory of Quality Research in Chinese Medicine & Faculty of Chinese Medicine, Macau University of Science and Technology, Macao [2]Department of Reproductive Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China [3]Key Laboratory of Epigenetics and Oncology, The Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, China [4]Department of Pathogenic Biology, School of Basic Medical, Southwest Medical University, Luzhou, Sichuan, China [5]Department of Microbiology, Tumor and Cell Biology, Centre for Translational Microbiome Research (CTMR), Karolinska Institute, Stockholm, Sweden
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关键词: Blood Mucus Vaginal microbiota Embryo transfer 16S rRNA gene sequencing

摘要:
The effect of blood and mucus on the catheter on pregnancy outcomes in frozen-embryo transfer (FET) cycles remains relatively under-investigated. To evaluate the influence of the presence of blood and mucus on the transfer catheter, along with the characteristics of vaginal microbiota on pregnancy outcomes in FET cycles, we comprehensively analyzed the clinical data of 816 patients. We meticulously recorded the potential traces of blood and mucus on the catheter following embryo transfer (ET). We examined three key outcome parameters including implantation rate (IR), clinical pregnancy rate (CPR), and biochemical pregnancy rate (BPR). Our results demonstrated that the presence of blood on the catheter was associated with a marked decrease in BPR and CPR, whereas the presence of mucus had no significant impact on BPR, CPR, and IR. To further elucidate whether the influence of blood on the catheter on pregnancy outcomes was mediated by vaginal microbiota imbalance, we examined the vaginal microbiota using 16S rRNA gene sequencing and conducted in-depth statistical analyses and correlation studies. Interestingly, the alpha and beta diversity of the vaginal microbiota between the blood group and non-blood group differed significantly. Importantly, the abundance of Lactobacillus was markedly decreased in the blood group. Our results indicate that the negative effect of the blood on the catheter on pregnancy may be attributed to the imbalance of vaginal microbiota. These results provide new insights into the potential mechanisms underlying the association between vaginal microbiota and blood on the catheter and their impact on pregnancy outcomes in FET cycles.Copyright © 2025 Elsevier B.V. All rights reserved.

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出版当年[2025]版:
大类 | 3 区 医学
小类 | 3 区 免疫学 3 区 生殖生物学
最新[2025]版:
大类 | 3 区 医学
小类 | 3 区 免疫学 3 区 生殖生物学
第一作者:
第一作者机构: [1]State Key Laboratory of Quality Research in Chinese Medicine & Faculty of Chinese Medicine, Macau University of Science and Technology, Macao [2]Department of Reproductive Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China [3]Key Laboratory of Epigenetics and Oncology, The Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, China
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通讯机构: [1]State Key Laboratory of Quality Research in Chinese Medicine & Faculty of Chinese Medicine, Macau University of Science and Technology, Macao [3]Key Laboratory of Epigenetics and Oncology, The Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, China
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