机构：[1]Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China[2]Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, China首都医科大学附属北京儿童医院[3]Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China四川省人民医院四川省肿瘤医院[4]Promegene Translational Research Institute, Shenzhen, China[5]Department of Epidemiology and Biostatistics, West China School of Public
Although human papillomavirus (HPV) infection plays a decisive role in causing tumors, its infection is insufficient for independently promoting cancer development and other co-factors facilitate the carcinogenic process. The objective of this study was to demonstrate the association between vaginal microbiota and high-risk human papillomavirus (HR-HPV) infection in women with and without bacterial vaginosis (BV). The study included 1,015 women aged 21-64 who participated in cervical cancer screening in two areas of China from 2018 to 2019. Women were collected cervical exfoliated cell specimens and reproductive tract secretions samples for HR-HPV, BV and microbial composition testing. From the non-BV&HPV- group (414 HPV-negative women without BV) to the non-BV&HPV+ group (108 HPV-positive women without BV), to the BV&HPV- group (330 HPV-negative women with BV) and then to the BV&HPV+ group (163 HPV positive-women with BV), microbial diversity increased. The relative abundance of 12 genera, including Gardnerella, Prevotell, and Sneathia increased, whilst Lactobacillus declined. Correlation networks of these genera and host characteristics were disrupted in the non-BV&HPV+ group, and the network trended more disordered in the BV&HPV+ group. Besides, multiple HPV infection, certain HPV genotype infection and cervical intraepithelial neoplasia (CIN) status were associated with some microbes and higher microbial diversity. HPV shifted the composition and diversity of vaginal microbiota, and BV further reinforced the trend. The relative abundance of 12 genera increased and 1 genus decreased on account of BV and HPV infection, and some genera including Lactobacillus, Prevotella and Sneathia were associated with some specific HPV genotypes infection and CIN. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.
基金：
Natural Science Foundation of China, 81973136
Sanming Project of Medicine in Shenzhen (grant SZSM201612042）
CAMS Innovation Fund for Medical Sciences (CIFMS): 2021-I2M-1-004
Research Fund for Young Scientist of Sichuan Cancer Hospital: YB2021036
第一作者机构：[1]Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China[2]Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, China
通讯作者：
通讯机构：[1]Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China[*1]Departments of Gynecological Oncology, National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing,100021,China.[*2]Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China
推荐引用方式(GB/T 7714)：
Liu Yujing,Li Tingyuan,Guo Ruochun,et al.The vaginal microbiota among the different status of human papillomavirus infection and bacterial vaginosis[J].JOURNAL OF MEDICAL VIROLOGY.2023,95(3):doi:10.1002/jmv.28595.
APA：
Liu Yujing,Li Tingyuan,Guo Ruochun,Chen Tingting,Wang Sumeng...&Chen Wen.(2023).The vaginal microbiota among the different status of human papillomavirus infection and bacterial vaginosis.JOURNAL OF MEDICAL VIROLOGY,95,(3)
MLA：
Liu Yujing,et al."The vaginal microbiota among the different status of human papillomavirus infection and bacterial vaginosis".JOURNAL OF MEDICAL VIROLOGY 95..3(2023)
