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Emerging glucose oxidase-delivering nanomedicines for enhanced tumor therapy

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机构: [1]Jiangxi Sci & Technol Normal Univ, Inst Organ Chem, Jiangxi Prov Key Lab Organ Funct Mol, Nanchang 330013, Peoples R China [2]Tongji Univ, Shanghai Pulm Hosp, Sch Med, Dept Thorac Surg, Shanghai 200092, Peoples R China [3]Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sichuan Acad Med Sci, Cent Lab, Chengdu 610072, Peoples R China [4]Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sichuan Acad Med Sci, Dept Med Ultrasound, Chengdu 610072, Peoples R China [5]Jiangxi Prov Peoples Hosp, Affiliated Hosp 1, Nanchang Med Coll, Inst Geriatr, Nanchang 330006, Peoples R China [6]Fudan Univ, State Key Lab Mol Engn Polymers, Lab Adv Mat, Dept Chem,Shanghai Key Lab Mol Catalysis & Innovat, Shanghai 200433, Peoples R China [7]Fudan Univ, iChem, Shanghai 200433, Peoples R China [8]Chongqing Med Univ, Affiliated Hosp 1, Lab Res Ctr, Chongqing 400016, Peoples R China
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关键词: Glucose oxidase Nanomedicine Tumor therapy Starvation therapy Synergistic therapy

摘要:
Abnormalities in glucose metabolism have been shown to characterize malignant tumors. Glucose depletion by glucose oxidase (GOD) has shown great potential in tumor therapy by causing tumor starvation. Since 2017, nanomedicines have been designed and utilized to deliver GOD for more precise and effective glucose modulation, which can overcome intrinsic limitations of different cancer therapeutic modalities by remodeling the tumor microenvironment to enhance antitumor therapy. To date, the topic of GOD-delivering nanomedicines for enhancing tumor therapy has not been comprehensively summarized. Herein, this review aims to provide an overview and discuss in detail recent advances in GOD delivery and directly involved starvation therapy strategies, GOD-sensitized various tumor therapy strategies, and GOD-mediated multimodal antitumor strategies. Finally, the challenges and outlooks for the future progress of the emerging tumor therapeutic nanomedicines are discussed. This review provides intuitive and specific insights to a broad audience in the fields of nanomedicines, biomaterials, and cancer therapy.

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基金编号: 52402344 20242BAB20098 2023BSQD11 2023BSQD13 2024SSY05141

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大类 | 1 区 医学
小类 | 1 区 药学 2 区 化学:综合
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大类 | 1 区 医学
小类 | 1 区 药学 2 区 化学:综合
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Q1 CHEMISTRY, MULTIDISCIPLINARY Q1 PHARMACOLOGY & PHARMACY

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第一作者机构: [1]Jiangxi Sci & Technol Normal Univ, Inst Organ Chem, Jiangxi Prov Key Lab Organ Funct Mol, Nanchang 330013, Peoples R China
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通讯机构: [3]Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sichuan Acad Med Sci, Cent Lab, Chengdu 610072, Peoples R China [4]Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sichuan Acad Med Sci, Dept Med Ultrasound, Chengdu 610072, Peoples R China
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