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Association between serum concentrations of perfluoroalkyl substances and global DNA methylation levels in peripheral blood leukocytes of Japanese women: A cross-sectional study

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Pubmed体系：
作者：
Itoh Hiroaki[1,2,*1] * ; Harada Kouji H[3] ; Kasuga Yoshio[4,5] ; Yokoyama Shiro[6] ; Onuma Hiroshi[6] ; Nishimura Hideki[7] ; Kusama Ritsu[8] ; Yokoyama Kazuhito[1,9] ; Zhu Jing[3,10] ; Harada Sassa Mariko[3] ; Yoshida Teruhiko[11] ; Tsugane Shoichiro[12] ; Iwasaki Motoki[2,12] ;
机构： [1]Department of Epidemiology and Environmental Health, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan [2]Division of Epidemiology, National Cancer Center Institute for Cancer Control, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan [3]Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida, Kyoto 606-8501, Japan [4]Department of Surgery, Nagano Matsushiro General Hospital, 183 Matsushiro, Matsushiro-cho, Nagano, Nagano 381-1231, Japan [5]Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan [6]Department of Breast and Thyroid Surgery, Nagano Red Cross Hospital, 5-22-1 Wakasato, Nagano, Nagano 380-8582, Japan [7]Department of Chest Surgery and Breast Surgery, Nagano Municipal Hospital, 1333-1 Tomitake, Nagano, Nagano 381-8551, Japan [8]Department of Surgery, Hokushin General Hospital, 1-5-63 Nishi, Nakano, Nagano 383-8505, Japan [9]Department of Epidemiology and Social Medicine, International University of Health and Welfare Graduate School of Public Health, 4-1-26 Akasaka, Minato-ku, Tokyo 107-8402, Japan [10]Department of Sanitary Technology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610061, China [11]Division of Genetics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104–0045, Japan [12]Division of Cohort Research, National Cancer Center Institute for Cancer Control, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
出处：
DOI： 10.1016/j.scitotenv.2022.159923
ISSN：

关键词： Persistent organic pollutants Epidemiology Epigenetics Perfluorochemicals Fluorinated compounds Isomer

摘要：
Global DNA methylation levels in peripheral blood leukocytes can be a biomarker for cancer risk; however, levels can be changed by various factors such as environmental pollutants. We investigated the association between serum concentrations of perfluoroalkyl substances (PFASs) and global DNA methylation levels of leukocytes in a cross-sectional study using the control group of a Japanese breast cancer case-control study [397 women with a mean age of 54.1 (SD 10.1) years]. Importantly, our analysis distinguished branched PFAS isomers as different from linear isomers. The serum concentrations of 20 PFASs were measured by in-port arylation gas-chromatography negative chemical ionization mass spectrometry. Global DNA methylation levels in peripheral blood leukocytes were measured using a luminometric methylation assay. Associations between log10-transformed serum PFAS concentrations and global DNA methylation levels were evaluated by regression coefficients in multivariable robust linear regression analyses. Serum concentrations of 13 PFASs were significantly associated with increased global DNA methylation levels in leukocytes. Global DNA methylation was significantly increased by 1.45 %-3.96 % per log10-unit increase of serum PFAS concentration. Our results indicate that exposure to PFASs may increase global DNA methylation levels in peripheral blood leukocytes of Japanese women.Copyright © 2022 Elsevier B.V. All rights reserved.

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外文
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出版当年[2022]版：
大类 | 1 区 环境科学与生态学
小类 | 1 区 环境科学
最新[2023]版：
大类 | 1 区 环境科学与生态学
小类 | 1 区 环境科学
第一作者：
第一作者机构： [1]Department of Epidemiology and Environmental Health, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan [2]Division of Epidemiology, National Cancer Center Institute for Cancer Control, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan [*1]Department of Epidemiology and Environmental Health, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
通讯作者：
通讯机构： [1]Department of Epidemiology and Environmental Health, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan [2]Division of Epidemiology, National Cancer Center Institute for Cancer Control, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan [*1]Department of Epidemiology and Environmental Health, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
推荐引用方式(GB/T 7714)：
Itoh Hiroaki,Harada Kouji H,Kasuga Yoshio,et al.Association between serum concentrations of perfluoroalkyl substances and global DNA methylation levels in peripheral blood leukocytes of Japanese women: A cross-sectional study[J].The Science of the total environment.2022,859(Pt 1):159923.doi:10.1016/j.scitotenv.2022.159923.
APA：
Itoh Hiroaki,Harada Kouji H,Kasuga Yoshio,Yokoyama Shiro,Onuma Hiroshi...&Iwasaki Motoki.(2022).Association between serum concentrations of perfluoroalkyl substances and global DNA methylation levels in peripheral blood leukocytes of Japanese women: A cross-sectional study.The Science of the total environment,859,(Pt 1)
MLA：
Itoh Hiroaki,et al."Association between serum concentrations of perfluoroalkyl substances and global DNA methylation levels in peripheral blood leukocytes of Japanese women: A cross-sectional study".The Science of the total environment 859..Pt 1(2022):159923

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