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Basic helix-loop-helix ARNT like 1 regulates the function of immune cells and participates in the development of immune-related diseases

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机构： [1]Chengdu Basebio Company, Tianfu Third Street, High-Tech Zone, Chengdu 610041, China. [2]Department of Urology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, First Ring Road, Qingyang District, Chengdu 610041, China. [3]Department of Public Research Platform, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, West Gate Street, Linhai City 317000, Zhejiang Province, China. [4]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Renmin South Road, Wuhou District, Chengdu 610041, China. [5]Department of Pathology, Ningbo Clinical Pathology Diagnosis Center, Huancheng North Road, Jiangbei District, Ningbo, Zhejiang Province, 315211, China. [6]Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, 625 Harrison Street, West Lafayette, IN 47907, USA. [7]Purdue Institute for Cancer Research, Purdue University, 615 W. State Street, West Lafayette, IN 47907, USA. [8]Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Jinzhai South Road, Shushan District, Hefei, Anhui 230032, China. [9]Department of Urology, Kyung Hee University, 26 Kyungheedae-Ro, Dongdaemun-Gu, South Korea. [10]Department of Earth Science and Engineering, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK. [11]Joint International Research Laboratory of Green Buildings and Built Environments (Ministry of Education), Chongqing University, Shapingba Street, Shapingba District, Chongqing 400044, China. [12]Department of Clinical Oncology, Queen Elizabeth Hospital, Gascoigne Road, Yau Ma Tei, Kowloon, Hong Kong SAR, China. [13]Division of Surgery & Interventional Science, University College London, Gower Street, London W1T 6JF, London W1W 7TS, UK.

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关键词： BMAL1 ARNTL1 Immuneresponse Autoimmunediseases Infectiousdiseases Cancer

摘要：

The circadian clock is an internal timekeeper system that regulates biological processes through a central circadian clock and peripheral clocks controlling various genes. Basic helix-loop-helix ARNT-like 1 (BMAL1), also known as aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL1), is a key component of the circadian clock. The deletion of BMAL1 alone can abolish the circadian rhythms of the human body. BMAL1 plays a critical role in immune cell function. Dysregulation of BMAL1 is linked to immune-related diseases such as autoimmune diseases, infectious diseases, and cancer, and vice versa. This review highlights the significant role of BMAL1 in governing immune cells, including their development, differentiation, migration, homing, metabolism, and effector functions. This study also explores how dysregulation of BMAL1 can have far-reaching implications and potentially contribute to the onset of immune-related diseases such as autoimmune diseases, infectious diseases, cancer, sepsis, and trauma. Furthermore, this review discusses treatments for immune-related diseases that target BMAL1 disorders. Understanding the impact of BMAL1 on immune function can provide insights into the pathogenesis of immune-related diseases and help in the development of more effective treatment strategies. Targeting BMAL1 has been demonstrated to achieve good efficacy in immune-related diseases, indicating its promising potential as a targetable therapeutic target in these diseases.© The Author(s) 2025. Published by Oxford University Press.

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大类 | 1 区医学

小类 | 1 区皮肤病学 1 区外科 2 区急救医学

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无

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Q1 DERMATOLOGY Q1 EMERGENCY MEDICINE Q1 SURGERY

影响因子： 6.3 最新[2023版] 6.7 最新五年平均 0 出版当年[2024版] 0 出版当年五年平均 0 出版前一年[2024版]

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第一作者机构： [1]Chengdu Basebio Company, Tianfu Third Street, High-Tech Zone, Chengdu 610041, China.

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通讯机构： [4]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Renmin South Road, Wuhou District, Chengdu 610041, China. [13]Division of Surgery & Interventional Science, University College London, Gower Street, London W1T 6JF, London W1W 7TS, UK.

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Basic helix-loop-helix ARNT like 1 regulates the function of immune cells and participates in the development of immune-related diseases

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