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BTK inhibition in primary central nervous system lymphoma: mechanisms, clinical efficacy, and future perspectives

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机构： [1]Thoracic Oncology Ward, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [2]Department of Thoracic Surgery and Institute of Thoracic Oncology, West China Hospital of Sichuan University, Sichuan University, Chengdu, Sichuan, China.

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关键词： B-cell receptor signaling Bruton’s tyrosine kinase (BTK) inhibitors primary central nervous system lymphoma (PCNSL) mechanism lymphoma

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The prognosis of primary central nervous system lymphoma (PCNSL) patients is relatively poor, and there is currently no standard treatment plan. Most patients choose high-dose chemotherapy based on methotrexate. While traditional chemotherapy combined with biological therapy has achieved limited results, some patients still do not respond to treatment or cannot tolerate its toxicity and side effects. Bruton's tyrosine kinase (BTK) is a key enzyme in B-cell receptor signaling, and its activation is critical for B-cell survival and proliferation. In recent years, BTK inhibitors have shown great potential in treating lymphomas derived from various B cells because of their strong targeting ability and relatively few side effects. They may also be a reasonable treatment choice for PCNSL. This article reviews the mechanism of action, clinical research, adverse reactions, and other issues of BTK inhibitors in treating PCNSL to provide a reference for individualized treatment of patients with PCNSL.Copyright © 2024 Xing, Zhao, Zhang and Wang.

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大类 | 3 区医学

小类 | 3 区肿瘤学

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第一作者机构： [1]Thoracic Oncology Ward, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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