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Critical Review on the Effect and Mechanism of Realgar Nanoparticles on Lymphoma: State of the Art on In-Vitro Biomedical Studies

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机构: [1]Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, PR China. [2]Department of Laboratory Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, PR China. [3]School of Biomedical Engineering, University of Melbourne, Melbourne, Australia. [4]Centre for Research Impact and Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura-140401, Punjab, India. [5]Department of Mechanical Engineering, Lebanese American University, Kraytem 1102-2801, Beirut, Lebanon. [6]Mechanical Engineering Department, University Centre for Research and Development, Chandigarh University, Mohali, Punjab, 140413, India. [7]Faculty of Pharmacy, Jabir Ibn Hayyan medical university, Najaf, Iraq. [8]Department of Medical Physics, Hilla University College, Babylon, Iraq. [9]Department of Nuclear and Renewable Energy, Ural Federal University Named After the First President of Russia, Boris Yeltsin, 19 Mira Street, 620002, Ekaterinburg, Russia. [10]Electrical Engineering Department, College of Engineering, King Khalid University, Abha 61421, Saudi Arabia.
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关键词: Realgar nanoparticles lymphoma anti-tumor effects

摘要:
Lymphoma is a malignant tumor caused by abnormal proliferation of lymphocytes in the lymphatic system. Conventional treatments for lymphoma often have limitations, and new therapeutic strategies need to be explored. Realgar is an ancient Chinese medicine that has been used for centuries to treat a variety of ailments due to its therapeutic potential for various diseases, including cancer. However, it is a time-consuming waste and has a low absorption rate in the gastrointestinal tract, so it has the disadvantages of oral dose, potential toxicity, and low bioavailability. Recently, the development of nanotechnology has promoted the nanization of realgar particles, which have better physicochemical properties and higher bioavailability. The antitumor activity of Realgar nanoparticles against lymphoma has been demonstrated in preclinical studies. Realgar nanoparticles exhibit cytotoxic effects by inducing apoptosis and inhibiting the growth and proliferation of lymphoma cells. Moreover, these nanoparticles exert immunomodulatory effects by enhancing the activity of immune cells and promoting the cytotoxicity of T lymphocytes against lymphoma cells. Additionally, realgar nanoparticles have been shown to inhibit tumor angiogenesis, thereby restricting the blood supply and nutrient availability to lymphoma cells. Despite promising preclinical data, further research on the role and mechanism of realgar nanoparticles in the treatment of lymphoma remains to be studied. Moreover, the translation of these findings into clinical practice requires rigorous evaluation through well-designed clinical trials. Realgar nanoparticles hold great potential as a novel therapeutic approach for lymphoma, and their development may contribute to the advancement of precision medicine in the field of oncology.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

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大类 | 4 区 材料科学
小类 | 4 区 材料科学:综合 4 区 纳米科技 4 区 物理:应用
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第一作者机构: [1]Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, PR China. [2]Department of Laboratory Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, PR China.
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通讯机构: [1]Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, PR China. [2]Department of Laboratory Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, PR China. [4]Centre for Research Impact and Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura-140401, Punjab, India. [5]Department of Mechanical Engineering, Lebanese American University, Kraytem 1102-2801, Beirut, Lebanon. [10]Electrical Engineering Department, College of Engineering, King Khalid University, Abha 61421, Saudi Arabia. [*1]Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, PR China [*2]Mechanical Engineering Department, University Centre for Research and Development, Chandigarh University, Mohali, Punjab, 140413 [*3]Electrical Engineering Department, College of Engineering, King Khalid University, Abha 61421, Saudi Arabia
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