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Dynamic human gut microbiome and immune shifts during an immersive psychosocial intervention program

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机构： [1]Department of Genetics, Stanford University School of Medicine, CA, USA [2]Stanford Center for Genomics and Personalized Medicine, Stanford University School of Medicine, CA, USA. [3]Stanford Healthcare Innovation Lab, Stanford University, CA, USA. [4]Department of Microbiology, College of Arts and Sciences, University of Washington, WA, USA. [5]West China Biomedical Big Data Center, West China Hospital, Sichuan University, Sichuan, China. [6]Oxford Centre for Microbiome Studies, Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK. [7]The Ohio State University Comprehensive Cancer Center, OH, USA. [8]Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA.

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关键词： gut microbiome psychosocial intervention neuro-inflammation CXCL-1

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Although depression is a leading cause of disability worldwide, the pathophysiological mechanisms underlying this disorder-particularly those involving the gut microbiome-are poorly understood.To investigate, we conducted a community-based observational study to explore complex associations between changes in the gut microbiome, cytokine levels, and depression symptoms in 52 participants (Mage = 49.56, SD = 13.31) receiving an immersive psychosocial intervention. A total of 142 multi-omics samples were collected from participants before, during, and three months after the nine-day inquiry-based stress reduction program.Results revealed that depression was associated with both an increased presence of putatively pathogenic bacteria and reduced microbial beta-diversity. Following the intervention, we observed reductions in neuroinflammatory cytokines and improvements in several mental health indicators. Interestingly, participants with a Prevotella-dominant microbiome showed milder symptoms when depressed, along with a more resilient microbiome and more favorable inflammatory cytokine profile, including reduced levels of CXCL-1.These findings reveal a potentially protective link between the Prevotella-dominant microbiome and depression, as evidenced by a reduced pro-inflammatory environment and fewer depressive symptoms. These insights, coupled with observed improvements in neuroinflammatory markers and mental health from the intervention, may highlight potential avenues for microbiome-targeted therapies for managing depression.Copyright © 2024. Published by Elsevier Inc.

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大类 | 2 区

医学

小类 | 2 区免疫学 2 区神经科学 2 区精神病学

第一作者：

第一作者机构： [1]Department of Genetics, Stanford University School of Medicine, CA, USA [2]Stanford Center for Genomics and Personalized Medicine, Stanford University School of Medicine, CA, USA.

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通讯机构： [1]Department of Genetics, Stanford University School of Medicine, CA, USA [2]Stanford Center for Genomics and Personalized Medicine, Stanford University School of Medicine, CA, USA. [3]Stanford Healthcare Innovation Lab, Stanford University, CA, USA.

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Dynamic human gut microbiome and immune shifts during an immersive psychosocial intervention program

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