机构：[1]Department of Genetics, Stanford University School of Medicine, CA, USA[2]Stanford Center for Genomics and Personalized Medicine, Stanford university School of[3]Stanford Healthcare Innovation Lab, Stanford University, CA, USA[4]Department of Microbiology, College of Arts and Sciences, University of Washington, WA, USA[5]West China Biomedical Big Data Center, West China Hospital, Sichuan University, Sichuan,四川大学华西医院[6]Oxford Centre for Microbiome Studies, Kennedy Institute of Rheumatology, University of Oxford, Oxford, USA[7]The Ohio State University Comprehensive Cancer Center, OH, USA[8]Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA
Depression is a leading cause of disability worldwide yet its underlying factors, particularly microbial associations, are poorly understood.We examined the longitudinal interplay between the microbiome and immune system in the context of depression during an immersive psychosocial intervention. 142 multi-omics samples were collected from 52 well-characterized participants before, during, and three months after a nine-day inquiry-based stress reduction program.We found that depression was associated with both an increased presence of putatively pathogenic bacteria and reduced microbial beta-diversity. Following the intervention, we observed reductions in neuroinflammatory cytokines and improvements in several mental health indicators. Interestingly, participants with a Prevotella-dominant microbiome showed milder symptoms when depressed, along with a more resilient microbiome and more favorable inflammatory cytokine profile, including reduced levels of CXCL-1.Our findings reveal a protective link between the Prevotella-dominant microbiome and depression, associated with a less inflammatory environment and moderated symptoms. These insights, coupled with observed improvements in neuroinflammatory markers and mental health from the intervention, highlight potential avenues for microbiome-targeted therapies in depression management.
基金：
NIH 5R01-MH116529, 5R25- 673 HG010857. G. M. S. was supported by grant #OPR21101 from the California Governor’s Office of 674 Planning and Research/California Initiative to Advance Precision Medicine. These organizations had no 675 role in planning, writing, editing, or reviewing this article, or in deciding to submit this article for the 676 public. X.Z. was supported by NIA fellowship Resource Centers for Minority Aging Research grant 677 P30AG059307. We also thank support to D.J.S. from NIA-K01AG070310, and J.S.J. from the Kennedy 678 Trust for Rheumatology Research.
语种：
外文
PubmedID：
第一作者：
第一作者机构：[1]Department of Genetics, Stanford University School of Medicine, CA, USA[2]Stanford Center for Genomics and Personalized Medicine, Stanford university School of
共同第一作者：
通讯作者：
通讯机构：[1]Department of Genetics, Stanford University School of Medicine, CA, USA[2]Stanford Center for Genomics and Personalized Medicine, Stanford university School of[3]Stanford Healthcare Innovation Lab, Stanford University, CA, USA
推荐引用方式(GB/T 7714)：
Zhou Xin,Ganz Ariel B,Rayner Andre,et al.Dynamic Human Gut Microbiome and Immune Shifts During an Immersive Psychosocial Therapeutic Program[J].Biorxiv : The Preprint Server For Biology.2024,doi:10.1101/2024.06.26.600881.
APA：
Zhou Xin,Ganz Ariel B,Rayner Andre,Cheng Tess Yan,Oba Haley...&Snyder Michael P.(2024).Dynamic Human Gut Microbiome and Immune Shifts During an Immersive Psychosocial Therapeutic Program.Biorxiv : The Preprint Server For Biology,,
MLA：
Zhou Xin,et al."Dynamic Human Gut Microbiome and Immune Shifts During an Immersive Psychosocial Therapeutic Program".Biorxiv : The Preprint Server For Biology .(2024)
