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Targeting the GDF15 Signalling for Obesity Treatment: Recent Advances and Emerging Challenges

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机构： [1]Division of Abdominal Tumor Multimodality Treatment, Department of Medical Oncology, Cancer Center and National Clinical Research Center for Geriatrics and Laboratory of Molecular Targeted Therapy in Oncology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China. [2]School of Physical Education and Sports, Sichuan University, Chengdu, China. [3]Research Institute of Molecular Exercise Science, Hungarian University of Sports Science, Budapest, Hungary.

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关键词： appetite suppression energy metabolism GDF15 GFRAL obesity weight loss

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The growth differentiation factor 15 (GDF15)-glial cell-derived neurotrophic factor family receptor alpha-like (GFRAL) pathway plays a crucial role in the regulation of metabolism, appetite and body weight control. Obesity is an increasingly prevalent chronic disease worldwide, necessitating effective treatment strategies. Recent preclinical and clinical studies have highlighted that targeting the GDF15-GFRAL signalling pathway is a promising approach for treating obesity, particularly because it has minimal impact on skeletal muscle mass, which is essential to preserve during weight loss. Given its distinctive mechanisms, the GDF15-GFRAL axis represents an attractive target for addressing various metabolic disorders, especially obesity. In this review, we will explore how the GDF15-GFRAL axis is regulated, its distribution in the body and its role in the regulation of metabolism, appetite and obesity. Additionally, we will discuss recent advances and potential challenges in targeting the GDF15-GFRAL axis for obesity treatment.© 2024 The Author(s). Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

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大类 | 2 区

医学

小类 | 2 区医学：研究与实验 3 区细胞生物学

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第一作者机构： [1]Division of Abdominal Tumor Multimodality Treatment, Department of Medical Oncology, Cancer Center and National Clinical Research Center for Geriatrics and Laboratory of Molecular Targeted Therapy in Oncology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China. [2]School of Physical Education and Sports, Sichuan University, Chengdu, China. [3]Research Institute of Molecular Exercise Science, Hungarian University of Sports Science, Budapest, Hungary.

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Targeting the GDF15 Signalling for Obesity Treatment: Recent Advances and Emerging Challenges

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