详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

Overview of growth differentiation factor 15 (GDF15) in metabolic diseases

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Department of Nephrology, Institute of Kidney Diseases, West China Hospital of Sichuan University, China [2]West China School of Medicine, Sichuan University, Chengdu, China [3]Health Management Center, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, China [4]Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China

出处：

DOI：

ISSN：

关键词： GDF15 GFRAL Metabolism Appetite regulation Obesity Anorexia

摘要：

GDF15 is a stress response cytokine and a distant member of the transforming growth factor beta (TGFβ) superfamily, its levels increase in response to cell stress and certain diseases in the serum. To exert its effects, GDF15 binds to glial-derived neurotrophic factor (GDNF) receptor alpha-like (GFRAL), which was firstly identified in 2017 and highly expressed in the brain stem. Many studies have demonstrated that elevated serum GDF15 is associated with anorexia and weight loss. Herein, we focus on the biology of GDF15, specifically how this circulating protein regulates appetite and metabolism in influencing energy homeostasis through its actions on hindbrain neurons to shed light on its impact on diseases such as obesity and anorexia/cachexia syndromes. It works as an endocrine factor and transmits metabolic signals leading to weight reduction effects by directly reducing appetite and indirectly affecting food intake through complex mechanisms, which could be a promising target for the treatment of energy-intake disorders.Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2024]版：

无

最新[2023]版：

大类 | 2 区

医学

小类 | 1 区药学 2 区医学：研究与实验

第一作者：

第一作者机构： [1]Department of Nephrology, Institute of Kidney Diseases, West China Hospital of Sichuan University, China

共同第一作者：

通讯作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Targeting the GDF15 Signalling for Obesity Treatment: Recent Advances and Emerging Challenges [2]Anti-adipogenesis and metabolism-regulating effects of heat-inactivated Streptococcus thermophilus MN-ZLW-002. [3]The Association Between Metabolic Status and Risk of Cancer Among Patients With Obesity: Metabolically Healthy Obesity vs. Metabolically Unhealthy Obesity. [4]Reassessing the causal role of obesity in breast cancer susceptibility: a comprehensive multivariable Mendelian randomization investigating the distribution and timing of exposure [5]Do Obesity-Related Traits Affect Prostate Cancer Risk through Serum Testosterone? A Mendelian Randomization Study [6]Image-Based Assessment of Obesity and Metabolic Pathway Alterations in Non-small Cell Lung Cancer [7]ELFN1-AS1 promotes GDF15-mediated immune escape of colorectal cancer from NK cells by facilitating GCN5 and SND1 association [8]Lipid metabolism and cancer. [9]Adiponectin ameliorates experimental periodontitis in diet-induced obesity mice. [10]Scoping review of obesity interventions: Research frontiers and publication status