机构：[1]College of Materials Science and Engineering, Sichuan University, Chengdu 610065, China.[2]Gastroenterology Department, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing 100005, China.
Detection of Helicobacter pylori is essential for the prevention of gastric cancer. By detecting the metabolized NH3, it was able to noninvasively reveal the state of H. pylori; however, it is still a challenge since the metabolized NH3 concentration is much lower for conventional gas sensors. Herein, we developed a MoS2-based NH3 sensor for continuous, real-time monitoring of H. pylori growth. The atomic thin layer and the all-exposed surface of MoS2 facilitate NH3 adsorption and charge transferring. A high-response NH3 sensor was prepared by surface decoration of MoS2 by depositing metal nanoparticles. The Fe-decorated MoS2 sensor outperformed with a high response of 40.9% for 5.7 ppm of NH3 at 25 ± 2 °C, low LOD (6.2 ppb), and long-term stability with a response of 12.5% for 5.7 ppm of NH3 after 5 months. The Fe-decorated MoS2 sensor was applied to the detection of H. pylori and the real-time in situ monitoring of its 92 h growth cycle. The NH3 release curve of the exponential phase during H. pylori growth was continuously monitored, and the NH3 concentration was quantified. The maximum specific rate of NH3 release was 0.195 ± 0.005 h-1, which is well-consistent with the nature of H. pylori growth. This study opens up a technological roadmap for noninvasive detection of H. pylori in the future.
基金：
This work was financially supported by the
Beijing Hospital 2023 Central High level Hospital Clinical
Research Medical Engineering Special Project (BJ-2023-103),
National Natural Science Foundation of China (52272160,
52002254, and U2330112), and Sichuan Science and
Technology Foundation (2024JDRC0021, 2023YFSY0002,
2022YFH0083, and 2022YFSY0045).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2024]版：
无
最新[2023]版：
大类|2 区材料科学
小类|2 区材料科学：综合2 区纳米科技
第一作者：
第一作者机构：[1]College of Materials Science and Engineering, Sichuan University, Chengdu 610065, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Zhao Minmin,Zhang Zhu,Tan Chao,et al.MoS2-Based NH3 Sensor for In Situ Helicobacter pylori Detection[J].ACS Applied Materials & Interfaces.2024,16(50):69798-69806.doi:10.1021/acsami.4c18702.
APA：
Zhao Minmin,Zhang Zhu,Tan Chao,Wang Wei,Yang Lei&Wang Zegao.(2024).MoS2-Based NH3 Sensor for In Situ Helicobacter pylori Detection.ACS Applied Materials & Interfaces,16,(50)
MLA：
Zhao Minmin,et al."MoS2-Based NH3 Sensor for In Situ Helicobacter pylori Detection".ACS Applied Materials & Interfaces 16..50(2024):69798-69806
材料科学