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Helicobacter pylori outer membrane protein families and related pathogenesis

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机构: [1]Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China [2]Laboratory of Infectious and Liver Diseases, Institute of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China [3]The Marshall Centre for Infectious Diseases, Research and Training, University of Western Australia, Crawley, 6009, Western Australia, Australia
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关键词: Helicobacter pylori Outer membrane proteins Pathogenesis Adhesins

摘要:
Helicobacter pylori infection is one of the most common bacterial infections worldwide and a major cause of chronic gastritis, peptic ulcers, and gastric cancer. The outer membrane proteins (OMPs) of H. pylori play crucial roles in its pathogenesis, acting as key mediators of bacterial adhesion, immune evasion, and interactions with the host. This review aims to provide a comprehensive overview of the various OMPs involved in H. pylori pathogenesis, including their roles as adhesins, porins, and in biofilm formation. Additionally, this review explores the involvement of OMPs in triggering proinflammatory responses that contribute to the development and progression of severe gastric diseases. By summarizing the current knowledge on H. pylori OMPs, this review highlights their significance as potential targets for therapeutic interventions aimed at preventing or mitigating H. pylori-associated diseases.Copyright © 2025 The Authors. Published by Elsevier Ltd.. All rights reserved.

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出版当年[2025]版:
大类 | 3 区 医学
小类 | 3 区 免疫学 3 区 微生物学
最新[2025]版:
大类 | 3 区 医学
小类 | 3 区 免疫学 3 区 微生物学
第一作者:
第一作者机构: [1]Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China [2]Laboratory of Infectious and Liver Diseases, Institute of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China
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通讯机构: [1]Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China [2]Laboratory of Infectious and Liver Diseases, Institute of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China
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