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Targeting Macrophage Migration Inhibitory Factor in Acute Pancreatitis and Pancreatic Cancer.

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资源类型：
Pubmed体系：
作者：
Wen Yongjian[1,2,3] ; Cai Wenhao[1,4] ; Yang Jingyu[1] ; Fu Xianghui[5] ; Putha Lohitha[6] ; Xia Qing[1] ; Windsor John A[2] ; Phillips Anthony R[2,3] ; Tyndall Joel D A[6] ; Du Dan[7] ; Liu Tingting[1] ; Huang Wei[1,4] ;
机构： [1]Department of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre and West China- Liverpool Biomedical Research Centre, West China Hospital of Sichuan University, Chengdu, China [2]Surgical and Translational Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand [3]Applied Surgery and Metabolism Laboratory, School of Biological Sciences, University of Auckland, Auckland, New Zealand [4]Liverpool Pancreatitis Research Group, Liverpool University Hospitals NHS Foundation Trust and Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom [5]Division of Endocrinology and Metabolism, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China [6]School of Pharmacy, University of Otago, Dunedin, New Zealand [7]West China-Washington Mitochondria and Metabolism Center, West China Hospital, Sichuan University, Chengdu, China
出处：
DOI： 10.3389/fphar.2021.638950
ISSN：

关键词： macrophage migration inhibitory factor acute inflammatory response toll-like receptor inflammasome acute pancreatitis pancreatic cancer

摘要：
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine implicated in the pathogenesis of inflammation and cancer. It is produced by various cells and circulating MIF has been identified as a biomarker for a range of diseases. Extracellular MIF mainly binds to the cluster of differentiation 74 (CD74)/CD44 to activate downstream signaling pathways. These in turn activate immune responses, enhance inflammation and can promote cancer cell proliferation and invasion. Extracellular MIF also binds to the C-X-C chemokine receptors cooperating with or without CD74 to activate chemokine response. Intracellular MIF is involved in Toll-like receptor and inflammasome-mediated inflammatory response. Pharmacological inhibition of MIF has been shown to hold great promise in treating inflammatory diseases and cancer, including small molecule MIF inhibitors targeting the tautomerase active site of MIF and antibodies that neutralize MIF. In the current review, we discuss the role of MIF signaling pathways in inflammation and cancer and summarize the recent advances of the role of MIF in experimental and clinical exocrine pancreatic diseases. We expect to provide insights into clinical translation of MIF antagonism as a strategy for treating acute pancreatitis and pancreatic cancer. Copyright © 2021 Wen, Cai, Yang, Fu, Putha, Xia, Windsor, Phillips, Tyndall, Du, Liu and Huang.

基金：
National Science Foundation of China (No. 81800575, TL; No. 81973632, WH; No. 81774120, QX); China-New Zealand Strategic Research Alliance Award (No. 2016YFE0101800, WH, QX); China-New Zealand International Cooperation Programme from Sichuan Provincial Department of Science and Technology (2019YFH0157, DD); China-New Zealand Scientist Exchange Programme (2018, WH; 2019, DD); The Ministry of Science and Technology of China (No. 2018ZX09201018-005, XF).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 2 区 医学
小类 | 2 区 药学
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 药学
第一作者：
第一作者机构： [1]Department of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre and West China- Liverpool Biomedical Research Centre, West China Hospital of Sichuan University, Chengdu, China [2]Surgical and Translational Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand [3]Applied Surgery and Metabolism Laboratory, School of Biological Sciences, University of Auckland, Auckland, New Zealand
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Wen Yongjian,Cai Wenhao,Yang Jingyu,et al.Targeting Macrophage Migration Inhibitory Factor in Acute Pancreatitis and Pancreatic Cancer.[J].Frontiers in pharmacology.2021,12:638950.doi:10.3389/fphar.2021.638950.
APA：
Wen Yongjian,Cai Wenhao,Yang Jingyu,Fu Xianghui,Putha Lohitha...&Huang Wei.(2021).Targeting Macrophage Migration Inhibitory Factor in Acute Pancreatitis and Pancreatic Cancer..Frontiers in pharmacology,12,
MLA：
Wen Yongjian,et al."Targeting Macrophage Migration Inhibitory Factor in Acute Pancreatitis and Pancreatic Cancer.".Frontiers in pharmacology 12.(2021):638950

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