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Dissecting the roles of prosaposin as an emerging therapeutic target for tumors and its underlying mechanisms

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机构: [1]The First Laboratory of Cancer Institute, The First Hospital of China Medical University, Shenyang, Liaoning Province 110001, China [2]Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China [3]Department of Laboratory Animal Science, China Medical University, Shenyang, China [4]Department of Oncology, The Fifth Affiliated Hospital of Guangxi Medical University & The First People’s Hospital of Nanning, Nanning, Guangxi, China [5]Department of Anorectal Surgery, the First Hospital of China Medical University, Shenyang, China
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关键词: Cancer Hallmarks PSAP Extracellular Therapeutic target Application

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As a dual-function protein, prosaposin (PSAP) is a lysosome-associated protein that participates in a variety of cellular processes. In the lysosome, PSAP is processed to activate enzymes that degrade lipids. In addition, PSAP proteins located extracellularly are involved in cancer progression, such as proliferation and tumor death suppression signaling. Moreover, under different situations, PSAP exhibits distinct metastasis potentials in tumors. However, comprehensive insight into PSAP in cancer progression has been lacking. Here, we provide a framework of the role of PSAP in cancer and its clinical application in cancer patients, providing a novel perspective on the clinical translation of PSAP.Copyright © 2024. Published by Elsevier Masson SAS.

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大类 | 2 区 医学
小类 | 1 区 药学 2 区 医学:研究与实验
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第一作者机构: [1]The First Laboratory of Cancer Institute, The First Hospital of China Medical University, Shenyang, Liaoning Province 110001, China
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