机构：[1]Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China[2]Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea[3]Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon 34113, Korea
Tryptophanyl-tRNA synthetase (WRS) is an essential enzyme that catalyzes the ligation of tryptophan (Trp) to its cognate tRNAtrp during translation via aminoacylation. Interestingly, WRS also plays physiopathological roles in diseases including sepsis, cancer, and autoimmune and brain diseases and has potential as a pharmacological target and therapeutic. However, WRS is still generally regarded simply as an enzyme that produces Trp in polypeptides; therefore, studies of the pharmacological effects, therapeutic targets, and mechanisms of action of WRS are still at an emerging stage. This review summarizes the involvement of WRS in human diseases. We hope that this will encourage further investigation into WRS as a potential target for drug development in various pathological states including infection, tumorigenesis, and autoimmune and brain diseases.
基金：
This work supported by “R&D Convergence Program” of the National Research Council
of Science and Technology (NST) grant (CAP-18-02-KRIBB) and KRIBB Research Initiative Program
by the Korea Government.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|2 区生物学
小类|3 区生化与分子生物学3 区化学综合
最新[2023]版：
大类|2 区生物学
小类|3 区生化与分子生物学3 区化学：综合
第一作者：
第一作者机构：[1]Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China[2]Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea
通讯作者：
通讯机构：[2]Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea[3]Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon 34113, Korea
推荐引用方式(GB/T 7714)：
Ahn Young Ha,Oh Se-Chan,Zhou Shengtao,et al.Tryptophanyl-tRNA Synthetase as a Potential Therapeutic Target.[J].International journal of molecular sciences.2021,22(9):doi:10.3390/ijms22094523.
APA：
Ahn Young Ha,Oh Se-Chan,Zhou Shengtao&Kim Tae-Don.(2021).Tryptophanyl-tRNA Synthetase as a Potential Therapeutic Target..International journal of molecular sciences,22,(9)
MLA：
Ahn Young Ha,et al."Tryptophanyl-tRNA Synthetase as a Potential Therapeutic Target.".International journal of molecular sciences 22..9(2021)
生物学