机构：[1]Department of Stomatology, The General Hospital of Western Theater Command PLA, Chengdu, China[2]Maine Health Institute for Research, Scarborough, ME, USA[3]State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Operative Dentistry and Endodontic, West China Hospital of Stomatology, Sichuan University, Chengdu, China[4]State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
Transforming growth factor-β (TGF-β) is a multifunctional cytokine that plays a vital role in regulating cell growth, differentiation and survival in various tissues. It participates in a variety of cellular processes, including cell apoptosis, cell migration and evasion, and plays a paradoxical role in tumor genesis and development. In the early stage of tumor, TGF-β inhibits the occurrence of tumor by inhibiting cell proliferation and regulating cell apoptosis. In the advanced stage of tumor, TGF-β promotes tumor development and affects prognosis by promoting cell survival and proliferation, cell migration and invasion, participates in immune escape, etc. In this article, we will review the paradoxical role of TGF-β on the occurrence and development of oral squamous cell carcinoma.
基金：
This study was supported by Science Foundation of
Sichuan (2023NSFSC0558).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|4 区医学
小类|4 区肿瘤学
最新[2023]版：
大类|4 区医学
小类|4 区肿瘤学
第一作者：
第一作者机构：[1]Department of Stomatology, The General Hospital of Western Theater Command PLA, Chengdu, China
通讯作者：
通讯机构：[*1]State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China
推荐引用方式(GB/T 7714)：
Peng Ruiting,Huang Yun,Huang Ping,et al.The paradoxical role of transforming growth factor-β in controlling oral squamous cell carcinoma development[J].Cancer Biomarkers : Section A Of Disease Markers.2024,40(3-4):241-250.doi:10.3233/CBM-230354.
APA：
Peng Ruiting,Huang Yun,Huang Ping,Liu Linyi,Cheng Lei&Peng Xian.(2024).The paradoxical role of transforming growth factor-β in controlling oral squamous cell carcinoma development.Cancer Biomarkers : Section A Of Disease Markers,40,(3-4)
MLA：
Peng Ruiting,et al."The paradoxical role of transforming growth factor-β in controlling oral squamous cell carcinoma development".Cancer Biomarkers : Section A Of Disease Markers 40..3-4(2024):241-250
