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Determining expression changes of ANO7 and SLC38A4 membrane transporters in colorectal cancer

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资源类型：
Pubmed体系：
作者：
Khosroshahi Elaheh Mohandesi[1,2] * ; Maghsoudloo Mazaher[3] * ; Fahimi Hossein[1,2] ; Mokhtari Khatere[4] ; Entezari Maliheh[2,1,*2] ; Peymani Maryam[5,*3] ; Hashemi Mehrdad[1,2,*4] ; Wan Runlan[6,7,*1] ;
机构： [1]Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. [2]Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical sciences, Islamic Azad University, Tehran, Iran. [3]Key Laboratory of Epigenetics and Oncology, The Research Center for Preclinical Medicine, Southwest Medical University, Luzhou 646000, Sichuan, China. [4]Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran. [5]Department of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran. [6]Department of Oncology, The Affiliated Hospital, Southwest Medical University, Luzhou 646000, China. [7]Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, (Collaborative Innovation Center for Prevention of Cardiovascular Diseases), Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China.
出处：
DOI： 10.1016/j.heliyon.2024.e34464
ISSN：

关键词： Colorectal cancer Membrane transporters ANO7 SLC38A4 Bioinformatic analysis RT-qPCR Cancer biomarkers

摘要：
Membrane transporters are proteins responsible for facilitating the movement of molecules within biological membranes. They play a vital role in maintaining cellular homeostasis by regulating the transport of nutrients, ions, and other molecules into and out of cells. Our aim is to identify biomarkers in colorectal cancer using membrane transporter proteins. We utilized COAD TCGA data for this purpose. Subsequently, we conducted differential gene analysis and feature selection using membrane transporter proteins. Furthermore, we identified two potential genes, including ANO7 and SLC38A4. To validate the expression profiles of ANO7 and SLC38A4, key genes in this context, RT-qPCR was employed on colorectal cancer samples and adjacent normal tissues. Additionally, utilizing GEPIA2, Kaplan-Meier survival analysis, and cBioPortal, we assessed the status of these genes in various cancers, examining their methylation and mutation patterns. In conclusion, we suggest that ANO7 and SLC38A4 serve as prognostic biomarkers in colorectal cancer.© 2024 The Authors.

基金：
This work was supported by grants from Postdoctoral Research Initiation Fund from Southwest Medical University (Grant No. 02/ 00170043), Science and Technology Project of Luzhou City (Grant No. 2022-SYF-63), and Sichuan Provincial Key Laboratory for Development and Utilization of Characteristic Horticultural Biological Resources, Chengdu Normal University (Grant No. 2023TSYY05).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2024]版：
无
最新[2023]版：
大类 | 3 区 综合性期刊
小类 | 3 区 综合性期刊
第一作者：
第一作者机构： [1]Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. [2]Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical sciences, Islamic Azad University, Tehran, Iran.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. [2]Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical sciences, Islamic Azad University, Tehran, Iran. [5]Department of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran. [6]Department of Oncology, The Affiliated Hospital, Southwest Medical University, Luzhou 646000, China. [7]Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, (Collaborative Innovation Center for Prevention of Cardiovascular Diseases), Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China. [*1]Department of Oncology, The Affiliated Hospital, Southwest Medical University, Luzhou 646000, China [*2]Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical sciences, Islamic Azad University, Tehran, Iran [*3]Department of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran [*4]Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
推荐引用方式(GB/T 7714)：
Khosroshahi Elaheh Mohandesi,Maghsoudloo Mazaher,Fahimi Hossein,et al.Determining expression changes of ANO7 and SLC38A4 membrane transporters in colorectal cancer[J].Heliyon.2024,10(14):e34464.doi:10.1016/j.heliyon.2024.e34464.
APA：
Khosroshahi Elaheh Mohandesi,Maghsoudloo Mazaher,Fahimi Hossein,Mokhtari Khatere,Entezari Maliheh...&Wan Runlan.(2024).Determining expression changes of ANO7 and SLC38A4 membrane transporters in colorectal cancer.Heliyon,10,(14)
MLA：
Khosroshahi Elaheh Mohandesi,et al."Determining expression changes of ANO7 and SLC38A4 membrane transporters in colorectal cancer".Heliyon 10..14(2024):e34464

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