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Leveraging FAM features to predict the prognosis of LGG patients and immunotherapy outcome

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资源类型：
Pubmed体系：
作者：
Lin Liangbin[1,2,3] * ; Yu Hui[1] * ; Xie Xuelu[4] * ; Lei Qingqiang[5] ; Chen Xuerui[1] ; Su Xu[1,6] ; Wang Xiuxuan[7,*2] ; Zhang Sunfu[1,*1] ; Yang Wenyong[1,*1] ;
机构： [1]Department of Neurosurgery and Urology, Medical Research Center, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, The Second Chengdu Hospital Affiliated to Chongqing Medical University Chengdu 610014, Sichuan, The People's Republic of China. [2]Obesity and Metabolism Medicine-Engineering Integration Laboratory, Department of General Surgery, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University Chengdu 610031, The People's Republic of China. [3]The Center of Gastrointestinal and Minimally Invasive Surgery, Department of General Surgery, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University Chengdu 610031, The People's Republic of China. [4]Department of Ophthalmology, West China School of Public Health and West China Forth Hospital, Sichuan University Chengdu 610041, Sichuan, The People's Republic of China. [5]Center of Bone Metabolism and Repair, Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University Chongqing 400000, The People's Republic of China. [6]College of Medicine, Southwest Jiaotong University Chengdu 610031, Sichuan, The People's Republic of China. [7]Department of Research and Development, Beijing DCTY Biotech Co., Ltd. Beijing 102200, The People's Republic of China.
出处：
DOI： 10.62347/GIGO3446
ISSN：

关键词： Tumor immunology LGG fatty acid metabolism prognostic features PHEX SHANK2 HOPX and LGALS1

摘要：
Heterogeneity at biological and transcriptomic levels poses a challenge in defining and typing low-grade glioma (LGG), leading to a critical need for specific molecular signatures to enhance diagnosis, therapy, and prognostic evaluation of LGG. This study focused on fatty acid metabolism (FAM) related genes and prognostic features to investigate the mechanisms and treatment strategies for LGG cell metastasis and invasion. By screening 158 FAM-related genes and clustering 512 LGG samples into two subtypes (C1 and C2), differential gene expression analysis and functional enrichment were performed. The immune cell scores and prognosis were compared between the two subtypes, with C1 showing poorer outcomes and higher immune scores. A four-gene signature (PHEX, SHANK2, HOPX, and LGALS1) was identified and validated across different datasets, demonstrating a stable predictive effect. Cellular experiments confirmed the roles of LGALS1 and HOPX in promoting tumor cell proliferation, migration, and invasion, while SHANK2 exhibited a suppressive effect. This four-gene signature based on FAM-related genes offers valuable insights for understanding the pathogenesis and clinical management of LGG.AJCR Copyright © 2024.

基金：
This work was supported by the National Natural Science Foundation of China (823- 03238, 82373336); The Science and Technology Support Program of Sichuan Province (2024NSFSC1945, 2024NSFSC1761, 2023- NSFSC0677, 2022YFQ0077), The Third People’s Hospital of Chengdu Scientific Research Project (2023PI18) and The Third People’s Hospital of Chengdu Clinical Research Program (CSY-YN-01-2023-013, CSY-YN-01-2023-025, CSY-YN-01-2023-005).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2024]版：
无
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 肿瘤学
第一作者：
第一作者机构： [1]Department of Neurosurgery and Urology, Medical Research Center, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, The Second Chengdu Hospital Affiliated to Chongqing Medical University Chengdu 610014, Sichuan, The People's Republic of China. [2]Obesity and Metabolism Medicine-Engineering Integration Laboratory, Department of General Surgery, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University Chengdu 610031, The People's Republic of China. [3]The Center of Gastrointestinal and Minimally Invasive Surgery, Department of General Surgery, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University Chengdu 610031, The People's Republic of China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Neurosurgery and Urology, Medical Research Center, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, The Second Chengdu Hospital Affiliated to Chongqing Medical University Chengdu 610014, Sichuan, The People's Republic of China. [7]Department of Research and Development, Beijing DCTY Biotech Co., Ltd. Beijing 102200, The People's Republic of China. [*1]Department of Neurosurgery and Urology, Medical Research Center, The Third People’s Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, The Second Chengdu Hospital Affiliated to Chongqing Medical University, Chengdu 610014, Sichuan, The People’s Republic of China [*2]Department of Research and Development, Beijing DCTY Biotech Co., Ltd., Beijing 102200, The People’s Republic of China
推荐引用方式(GB/T 7714)：
Lin Liangbin,Yu Hui,Xie Xuelu,et al.Leveraging FAM features to predict the prognosis of LGG patients and immunotherapy outcome[J].American Journal Of Cancer Research.2024,14(6):2731-2754.doi:10.62347/GIGO3446.
APA：
Lin Liangbin,Yu Hui,Xie Xuelu,Lei Qingqiang,Chen Xuerui...&Yang Wenyong.(2024).Leveraging FAM features to predict the prognosis of LGG patients and immunotherapy outcome.American Journal Of Cancer Research,14,(6)
MLA：
Lin Liangbin,et al."Leveraging FAM features to predict the prognosis of LGG patients and immunotherapy outcome".American Journal Of Cancer Research 14..6(2024):2731-2754

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