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The PDZ Domain of the E Protein in SARS-CoV Induces Carcinogenesis and Poor Prognosis in LUAD

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机构： [1]School of Basic Medical Sciences, Chengdu Medical College, Chengdu 610500, China. [2]School of Biosciences and Technology, Chengdu Medical College, Chengdu 610500, China. [3]Department of Immunology, School of Basic Medical Sciences, Chengdu Medical College, Chengdu, Sichuan 610500, China. [4]Radiotherapy Center, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China

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关键词： SARS-CoV-1 PBM envelope protein LUAD bioinformatics

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In both lung adenocarcinoma (LUAD) and severe acute respiratory syndrome (SARS), uncontrolled inflammation can be detected in lung tissue. The PDZ-binding motif (PBM) in the SARS-CoV-1 E protein has been demonstrated to be a virulence factor that induces a cytokine storm.To identify gene expression fluctuations induced by PBM, microarray sequencing data of lung tissue infected with wild-type (SARS-CoV-1-E-wt) or recombinant virus (SARS-CoV-1-E-mutPBM) were analyzed, followed by functional enrichment analysis. To understand the role of the screened genes in LUAD, overall survival and immune correlation were calculated.A total of 12 genes might participate in the initial and developmental stages of LUAD through expression variation and mutation. Moreover, dysregulation of a total of 12 genes could lead to a poorer prognosis. In addition, the downregulation of MAMDC2 and ITGA8 by PBM could also affect patient prognosis. Although the conserved PBM (-D-L-L-V-) can be found at the end of the carboxyl terminus in multiple E proteins of coronaviruses, the specific function of each protein depends on the entire amino acid sequence.In summary, PBM containing the SARS-CoV-1 E protein promoted the carcinogenesis of LUAD by dysregulating important gene expression profiles and subsequently influencing the immune response and overall prognosis.Copyright © 2024. Published by Elsevier Masson SAS.

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出版当年[2023]版：

大类 | 4 区医学

小类 | 4 区免疫学 4 区传染病学 4 区微生物学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区免疫学 4 区传染病学 4 区微生物学

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第一作者机构： [1]School of Basic Medical Sciences, Chengdu Medical College, Chengdu 610500, China. [3]Department of Immunology, School of Basic Medical Sciences, Chengdu Medical College, Chengdu, Sichuan 610500, China.

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