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The CRISPR-Cas system in molecular diagnostics

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收录情况： ◇ SCIE

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机构： [1]Department of Pharmacy, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu 610041, China. [2]Department of Pathology, Suining Central Hospital, Suining 629000, China

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关键词： CRISPR Detection Molecular diagnosis Biosensor Cas9 Cas12 Cas13 COVID-19

摘要：

Robust, sensitive, and rapid molecular detection tools are essential prerequisites for disease diagnosis and epidemiological control. However, the current mainstream tests necessitate expensive equipment and specialized operators, impeding the advancement of molecular diagnostics. The CRISPR-Cas system is an integral component of the bacterial adaptive immune system, wherein Cas proteins recognize PAM sequences by binding to CRISPR RNA, subsequently triggering DNA or RNA cleavage. The discovery of the CRISPR-Cas system has invigorated molecular diagnostics. With further in-depth research on this system, its application in molecular diagnosis is flourishing. In this review, we provide a comprehensive overview of recent research progress on the CRISPR-Cas system, specifically focusing on its application in molecular diagnosis.Copyright © 2024 Elsevier B.V. All rights reserved.

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出版当年[2023]版：

大类 | 3 区医学

小类 | 3 区医学实验技术

最新[2023]版：

大类 | 3 区医学

小类 | 3 区医学实验技术

JCR分区：

出版当年[2023]版：

Q2 MEDICAL LABORATORY TECHNOLOGY

最新[2023]版：

Q2 MEDICAL LABORATORY TECHNOLOGY

影响因子： 3.2 最新[2023版] 3.7 最新五年平均 3.2 出版当年[2023版] 0 出版当年五年平均 3.2 出版前一年[2023版]

第一作者：

第一作者机构： [1]Department of Pharmacy, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu 610041, China.

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