机构：[1]School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, Heilongjiang, 150090, China.[2]Department of Nutrition, Food Safety and Toxicology, West China School of Public Health and West China Forth Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.[3]R&D Center, Inner Mongolia Meng Niu Dairy Industry (Group) Co., Ltd, Hohhot, Inner Mongolia, 011500, China.[4]College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong, 266003, China.
Metabolic syndrome and obesity have become serious threats to public health worldwide. This study was conducted to evaluate the anti-adipogenesis and metabolism-regulating effects of heat-inactivated Streptococcus thermophilus MN-ZLW-002 (MN-ZLW-002), which can be used as a yogurt starter. In vitro study suggested that MN-ZLW-002 stimulated the RAW264.7 macrophages to produce significant amounts of interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF)-α and induced intense phosphorylation of P38, p44/42 MAPK, and nuclear factor κB. MN-ZLW-002-stimulated RAW264.7-conditioned medium (CM) notably suppressed the differentiation and adipogenesis of 3T3-L1 pre-adipocytes. The 12-week in vivo study suggested that orally administered MN-ZLW-002 significantly reduced the weight gain of mice caused by the high-fat diet (HFD) at weeks 3-8; decreased fasting blood glucose levels at week 4 and week 8; decreased serum total triglyceride level at week 12. MN-ZLW-002 also reduced serum IL-1β and chemokine ligand 3 levels in the HFD-fed mice. These findings suggest that heat-inactivated MN-ZLW-002 can suppress adipocytes differentiation and lipid accumulation by regulating the immune response, possibly via the release of cytokines, particularly TNF-α; MN-ZLW-002 can improve metabolism-related indicators in the early stage of HFD intervention and regulate the related pro-inflammatory immune response.
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基金：
This study was financially supported by the National Key R&D Program of China (NO.2018YFC1604302) and the National Natural Science Foundation of China (NO. 31771987).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|4 区生物学
小类|4 区生物工程与应用微生物4 区微生物学
最新[2023]版：
大类|4 区生物学
小类|4 区生物工程与应用微生物4 区微生物学
第一作者：
第一作者机构：[1]School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, Heilongjiang, 150090, China.
通讯作者：
通讯机构：[1]School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, Heilongjiang, 150090, China.[4]College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong, 266003, China.[*1]College of Food Science and Engineering, Ocean University of China, Qingdao, 266003, China.[*2]School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150090, China
推荐引用方式(GB/T 7714)：
Xiaohong Kang,Huijing Liang,Yating Luo,et al.Anti-adipogenesis and metabolism-regulating effects of heat-inactivated Streptococcus thermophilus MN-ZLW-002.[J].Letters in applied microbiology.2021,72(6):677-687.doi:10.1111/lam.13398.
APA：
Xiaohong Kang,Huijing Liang,Yating Luo,Zhouyong Li,Fang He...&Lanwei Zhang.(2021).Anti-adipogenesis and metabolism-regulating effects of heat-inactivated Streptococcus thermophilus MN-ZLW-002..Letters in applied microbiology,72,(6)
MLA：
Xiaohong Kang,et al."Anti-adipogenesis and metabolism-regulating effects of heat-inactivated Streptococcus thermophilus MN-ZLW-002.".Letters in applied microbiology 72..6(2021):677-687
