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Single-cell profiling reveals the metastasis-associated immune signature of hepatocellular carcinoma

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资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Zhong Deyuan[1,2] * ; Shi Ying[2] * ; Ma Wenzhe[3] * ; Liang Yuxin[1,2] ; Liu Hanjie[1] ; Qin Yingying[1] ; Zhang Lu[4] ; Yang Qinyan[1] ; Huang Xiaolun[1,2] ; Lu Yuanjun[4,*2] ; Shang Jin[1,4,*1] ;
机构： [1]Liver Transplantation Center and HBP Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China. [2]School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China. [3]State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau SAR, China. [4]Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.
出处：
DOI： 10.1002/iid3.1264
ISSN：

关键词： dendritic cells hepatocellular carcinoma metastasis single cell RNA sequencing Treg cells tumor immune microenvironment

摘要：
Metastasis is the leading cause of mortality in hepatocellular carcinoma (HCC). The metastasis-associated immune signature in HCC is worth exploring.Bioinformatic analysis was conducted based on the single-cell transcriptome data derived from HCC patients in different stages. Cellular composition, pseudotime state transition, and cell-cell interaction were further analyzed and verified.Generally, HCC with metastasis exhibited suppressive immune microenvironment, while HCC without metastasis exhibited active immune microenvironment. Concretely, effector regulatory T cells (eTregs) were found to be enriched in HCC with metastasis. PHLDA1 was identified as one of exhaustion-specific genes and verified to be associated with worse prognosis in HCC patients. Moreover, A novel cluster of CCR7+ dendritic cells (DCs) was identified with high expression of maturation and migration marker genes. Pseudotime analysis showed that inhibition of differentiation occurred in CCR7+ DCs rather than cDC1 in HCC with metastasis. Furthermore, interaction analysis showed that the reduction of CCR7+ DCs lead to impaired CCR7/CCL19 interaction in HCC with metastasis.HCC with metastasis exhibited upregulation of exhaustion-specific genes of eTregs and inhibition of CCL signal of a novel DC cluster, which added new dimensions to the immune landscape and provided new immune therapeutic targets in advanced HCC.© 2024 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.

基金：
The Excellent Youth Fund of Sichuan Cancer Hospital, Grant/Award Number: YB2024002; Sichuan Provincial Science and Technology Plan Project, Grant/Award Number: 2023YFSY0043
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2024]版：
无
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 免疫学
JCR分区：
出版当年[2024]版：
无
最新[2023]版：
Q3 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2023版]

第一作者：
第一作者机构： [1]Liver Transplantation Center and HBP Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China. [2]School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
共同第一作者：
通讯作者：
通讯机构： [1]Liver Transplantation Center and HBP Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China. [4]Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China. [*1]Liver Transplantation Center and HBP Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China [*2]Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China
推荐引用方式(GB/T 7714)：
Zhong Deyuan,Shi Ying,Ma Wenzhe,et al.Single-cell profiling reveals the metastasis-associated immune signature of hepatocellular carcinoma[J].IMMUNITY INFLAMMATION AND DISEASE.2024,12(5):e1264.doi:10.1002/iid3.1264.
APA：
Zhong Deyuan,Shi Ying,Ma Wenzhe,Liang Yuxin,Liu Hanjie...&Shang Jin.(2024).Single-cell profiling reveals the metastasis-associated immune signature of hepatocellular carcinoma.IMMUNITY INFLAMMATION AND DISEASE,12,(5)
MLA：
Zhong Deyuan,et al."Single-cell profiling reveals the metastasis-associated immune signature of hepatocellular carcinoma".IMMUNITY INFLAMMATION AND DISEASE 12..5(2024):e1264

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