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Natural products and derivatives in renal, urothelial and testicular cancers: Targeting signaling pathways and therapeutic potential

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机构： [1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China [2]Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China [3]Department of Urology, Kyung Hee University, South Korea [4]Department of pathology, Ningbo Clinical Pathology Diagnosis Center, Ningbo City, Zhejiang Province, 315211, China [5]Department of Rehabilitation, West Kyushu University, Japan [6]Department of Rehabilitation, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, PR China [7]Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA

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关键词： Urothelial carcinoma Renal cancer Testicular cancer Natural products Signal pathways

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Natural products have demonstrated significant potential in cancer drug discovery, particularly in renal cancer (RCa), urothelial carcinoma (UC), and testicular cancer (TC).This review aims to examine the effects of natural products on RCa, UC and TC.systematic review METHODS: PubMed and Web of Science databases were retrieved to search studies about the effects of natural products and derivatives on these cancers. Relevant publications in the reference list of enrolled studies were also checked.This review highlighted their diverse impacts on key aspects such as cell growth, apoptosis, metastasis, therapy response, and the immune microenvironment. Natural products not only hold promise for novel drug development but also enhance the efficacy of existing chemotherapy and immunotherapy. Importantly, we exert their effects through modulation of critical pathways and target genes, including the PI3K/AKT pathway, NF-κB pathway, STAT pathway and MAPK pathway, among others in RCa, UC, and TC.These mechanistic insights provide valuable guidance for researchers, facilitating the selection of promising natural products for cancer management and offering potential avenues for further gene regulation studies in the context of cancer treatment.Copyright © 2024 Elsevier GmbH. All rights reserved.

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出版当年[2023]版：

大类 | 1 区

医学

小类 | 1 区药物化学 1 区全科医学与补充医学 1 区药学 1 区植物科学

最新[2023]版：

大类 | 1 区

医学

小类 | 1 区药物化学 1 区全科医学与补充医学 1 区药学 1 区植物科学

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第一作者机构： [1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China

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通讯机构： [1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China [6]Department of Rehabilitation, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, PR China [*1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China [*2]Department of Rehabilitation, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, PR China

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