机构：[a]Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences and Sichuan Provincial People`s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, P. R. China四川省人民医院[b]School of Pharmacy, North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China[c]Molecular Imaging Innovations Institute (MI3), Department of Radiology, Weill Cornell Medical College, New York, NY 10065, USA[d]Department of Civil and Environmental Engineering, Zhejiang University, Hangzhou, Zhejiang 310000, P.R. China
Background: Apoptosis is one of the pathways of programmed cell death (PCD), which leads to pathognomic cellular changes different from cellular necrosis. It includes the death receptor pathway and the mitochondrial pathway, both of which involve many key proteins abnormally expressed in apoptosis-related diseases, such as cancer. The majority of anti-cancer natural products promote apoptosis to induce cancer cell death. In this review, we aim to survey the current knowledge on key apoptotic proteins and some representative natural products that can induce cancer cell apoptosis by regulating these proteins. Method: We reviewed the recent relative literatures using a structured search of bibliographic databases, and the keywords, such as natural products, cancer therapy, and apoptosis pathway, were used for inclusion/exclusion criteria. Results: One hundred and seventy-one papers are included in this review. Numerous natural products have been reported to induce cell apoptosis by regulating the expression of key apoptotic proteins, leading to a variety of antitumor effects. This review identifies the major apoptotic proteins and elaborates the interaction between the apoptotic proteins and various natural anti-cancer products. Conclusion: This review provides substantial evidences of apoptosis pathways in cancer cells and the apoptotic proteins modulated by active natural products, which may help to gain a comprehensive understanding for the development of natural drugs for better cancer treatment.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81402500]; National Key Specialty Construction Project of Clinical Pharmacy [30305030698]; Youth Science and Technology Foundation of Science and Technology Department of Sichuan Province [2016JQ0031]; Sichuan Province Health and Family Planning Commission scientific research project [17PJ554]
第一作者机构：[a]Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences and Sichuan Provincial People`s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, P. R. China
共同第一作者：
通讯作者：
通讯机构：[a]Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences and Sichuan Provincial People`s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, P. R. China[*1]Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences and Sichuan Provincial People`s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, P. R. China
推荐引用方式(GB/T 7714)：
Yan Wang,Jian Zhong,Jiaojiao Bai,et al.The Application of Natural Products in Cancer Therapy by Targeting Apoptosis Pathways[J].CURRENT DRUG METABOLISM.2018,19(9):739-749.doi:10.2174/1389200219666180511154722.
APA：
Yan Wang,Jian Zhong,Jiaojiao Bai,Rongsheng Tong,Feifei An...&Lulu Cai.(2018).The Application of Natural Products in Cancer Therapy by Targeting Apoptosis Pathways.CURRENT DRUG METABOLISM,19,(9)
MLA：
Yan Wang,et al."The Application of Natural Products in Cancer Therapy by Targeting Apoptosis Pathways".CURRENT DRUG METABOLISM 19..9(2018):739-749
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