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Use of statins and risks of ovarian, uterine, and cervical diseases: a cohort study in the UK Biobank

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机构： [1]Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. [2]Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. [3]NMPA Key Laboratory for Technical Research On Drug Products In Vitro and In Vivo Correlation, Chengdu, Sichuan, China. [4]Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, Sichuan, China. [5]West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [6]Medical Big Data Center, Sichuan University, Chengdu, Sichuan, China. [7]West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [8]Medical Big Data Center, Sichuan University, Chengdu, Sichuan, China. [9]West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [10]Medical Big Data Center, Sichuan University, Chengdu, Sichuan, China. [11]Division of Nephrology, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [12]Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. [13]Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. [14]NMPA Key Laboratory for Technical Research On Drug Products In Vitro and In Vivo Correlation, Chengdu, Sichuan, China. [15]Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, Sichuan, China. [16]Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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关键词： Statins Cohort study Risk Cervical cancer Polycystic ovarian syndrome

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To examine the associations between use of statins and risks of various ovarian, uterine, and cervical diseases, including ovarian cancer, endometrial cancer, cervical cancer, ovarian cyst, polycystic ovarian syndrome, endometriosis, endometrial hyperplasia, endometrial polyp, and cervical polyp.We conducted a cohort study among female participants in the UK Biobank. Information on the use of statins was collected through verbal interview. Outcome information was obtained by linking to national cancer registry data and hospital inpatient data. We used Cox proportional hazards regression to examine the associations.A total of 180,855 female participants (18,403 statin users and 162,452 non-users) were included. Use of statins was significantly associated with increased risks of cervical cancer (adjusted hazard ratio (HR), 1.55; 95% confidence interval (95% CI), 1.05-2.30) and polycystic ovarian syndrome (adjusted HR, 4.39; 95% CI, 1.68-11.49). However, we observed no significant association between use of statins and risk of ovarian cancer, endometrial cancer, ovarian cyst, endometriosis, endometrial hyperplasia, endometrial polyp, or cervical polyp.Our findings suggest that use of statins is associated with increased risks of cervical cancer and polycystic ovarian syndrome, but is not associated with increased or decreased risk of ovarian cancer, endometrial cancer, ovarian cyst, endometriosis, endometrial polyp, or cervical polyp.© 2024. The Author(s).

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出版当年[2023]版：

大类 | 3 区医学

小类 | 3 区药学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区药学

第一作者：

第一作者机构： [1]Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. [2]Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. [3]NMPA Key Laboratory for Technical Research On Drug Products In Vitro and In Vivo Correlation, Chengdu, Sichuan, China. [4]Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, Sichuan, China.

通讯作者：

通讯机构： [7]West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [8]Medical Big Data Center, Sichuan University, Chengdu, Sichuan, China. [9]West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [10]Medical Big Data Center, Sichuan University, Chengdu, Sichuan, China. [11]Division of Nephrology, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [12]Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. [13]Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. [14]NMPA Key Laboratory for Technical Research On Drug Products In Vitro and In Vivo Correlation, Chengdu, Sichuan, China. [15]Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, Sichuan, China. [16]Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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Use of statins and risks of ovarian, uterine, and cervical diseases: a cohort study in the UK Biobank

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