机构:[1]Department of Urology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.[2]Department of Hepato-Biliary-Pancrease, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, China.[3]Department of Surgery, Binhai New Area Hospital of Traditional Chinese Medicine, Tianjin, China.[4]Department of Urology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.[5]Institute of Nephrology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.[6]Anorectal Disease Institute of Shuguang Hospital, Shanghai, China.[7]Department of Anorectal Surgery, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Urologic malignancies are the major causes of morbidity and mortality in men over 40 years old, accounting for more than 20% of all malignant tumors. Several meta-analyses are shown that statin exposure can reduce the morbidity and mortality of various urologic cancers. The adjuvant roles of statin in tumor prevention and anti-tumor activity are now being gradually recognized and have gained attention. Nevertheless, to date, multiple clinical studies and meta-analyses found inconsistent results of their anti-cancer effects. This study aims to evaluate the credibility of the published systematic reviews and meta-analyses that assessed the effects of statin exposure for the incidence and mortality of urologic cancers through an umbrella review.The guidance of overviews of systematic reviews reported in the Cochrane Handbook for Systematic Reviews of interventions will be followed while performing and reporting this umbrella review. This project was registered in PROSPERO with the registration number of CRD42020208854. PubMed, Embase and Cochrane Library will be searched for systematic reviews to identify and appraise systematic reviews or meta-analyses of interventional and observational studies examining statin use and the risks of urologic cancer incidence and mortality without language restriction. The search will be carried out on 10 February 2022. Systematic reviews based on qualitative, quantitative or mixed-methods studies will be involved and critically evaluated by two authors using the Assessment of Multiple Systematic Reviews 2 (AMSTAR2, an updated version of AMSTAR) tool. We will determine the level of evidence using the GRADE (Grading of Recommendations, Assessment, Development, and Evaluations) tool. The summary effect estimates will be calculated using random-effects models. Between- study heterogeneity will be assessed using the I2 statistic. Furthermore, we will also assess the evidence of excess significance bias and evidence of small study effects.Ethics approval is not required as we will search and gather data based on the published systematic reviews and meta-analyses. We plan to publish the results of this umbrella review in a peer-reviewed journal and will be presented at a urological disease conference. All the relevant additional data will also be uploaded to the online open access databases.CRD42020208854.
语种:
外文
PubmedID:
中科院(CAS)分区:
出版当年[2022]版:
大类|3 区综合性期刊
小类|3 区综合性期刊
最新[2023]版:
大类|3 区综合性期刊
小类|3 区综合性期刊
第一作者:
第一作者机构:[1]Department of Urology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
共同第一作者:
通讯作者:
通讯机构:[6]Anorectal Disease Institute of Shuguang Hospital, Shanghai, China.[7]Department of Anorectal Surgery, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
推荐引用方式(GB/T 7714):
Zhai Xinyu,Yi Pengsheng,Wang Xitao,et al.Effect of statins on risk and mortality of urologic malignancies: Protocol of an umbrella review.[J].PloS one.2022,17(3):e0264076.doi:10.1371/journal.pone.0264076.
APA:
Zhai Xinyu,Yi Pengsheng,Wang Xitao,Wang Haifeng,Yang Xuejun...&Ge Minyao.(2022).Effect of statins on risk and mortality of urologic malignancies: Protocol of an umbrella review..PloS one,17,(3)
MLA:
Zhai Xinyu,et al."Effect of statins on risk and mortality of urologic malignancies: Protocol of an umbrella review.".PloS one 17..3(2022):e0264076