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Pachymic acid protects oocyte by improving the ovarian microenvironment in polycystic ovary syndrome mice†.

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机构： [1]Organ Transplantation Institute, School of Medicine, Xiamen University, Xiamen, China [2]Clinical Pharmacy Office, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China [3]Department of Gynaecology and Obstetrics, Affiliated Xiang’an Hospital of Xiamen University, Xiamen, China [4]Medical College, Guangxi University, Nanning, China [5]Reproductive Medicine Center, The Maternal and Child Health Care Hospital, Xiangtan, China [6]Department of Gynaecology, Affiliated Hospital of Putian University, Putian University, Putian, China [7]Chengdu Research Base of Giant Panda Breeding, Sichuan Key Laboratory of Conservation Biology for Endangered Wildlife, Chengdu, China [8]Department of Basic Medicine, School of Medicine, Xiamen University, Xiamen, China [9]The Reproductive Medical Center Nanning Second People’s Hospital, Nanning, China

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Women with polycystic ovary syndrome (PCOS) are characterized by endocrine disorders accompanied by a decline in oocyte quality. In this study, we generated a PCOS mice model by hypodermic injection of dehydroepiandrosterone, and metformin was used as a positive control drug to study the effect of pachymic acid (PA) on endocrine and oocyte quality in PCOS mice. Compared with the model group, the mice treated with PA showed the following changes (slower weight gain, improved abnormal metabolism; increased development potential of GV oocytes, reduced number of abnormal MII oocytes, and damaged embryos; lower expression of ovarian-related genes in ovarian tissue and pro-inflammatory cytokines in adipose tissue). All these aspects show similar effects on metformin. Most notably, PA is superior to metformin in improving inflammation of adipose tissue and mitochondrial abnormalities. It is suggested that PA has the similar effect with metformin, which can improve the endocrine environment and oocyte quality of PCOS mice. These findings suggest that PA has the similar effect with metformin, which can improve the endocrine environment and oocyte quality of PCOS mice.© The Author(s) 2020. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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出版当年[2020]版：

大类 | 2 区生物学

小类 | 2 区生殖生物学

最新[2023]版：

大类 | 2 区生物学

小类 | 3 区生殖生物学

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第一作者机构： [1]Organ Transplantation Institute, School of Medicine, Xiamen University, Xiamen, China [2]Clinical Pharmacy Office, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

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通讯作者：

通讯机构： [1]Organ Transplantation Institute, School of Medicine, Xiamen University, Xiamen, China [8]Department of Basic Medicine, School of Medicine, Xiamen University, Xiamen, China [9]The Reproductive Medical Center Nanning Second People’s Hospital, Nanning, China [*1]The Reproductive Medical Center, Nanning Second People’s Hospital, Dancun Road 13, 530031 Nanning, China [*2]Department of Basic Medicine, School of Medicine, Xiamen University, Xiang-An S Rd, 361102 Xiamen, Fujian, China

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