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SKA3 targeted therapies in cancer precision surgery: bridging bench discoveries to clinical applications-review article

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机构： [1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China. [2]Department of Rehabilitation, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, P.R. China. [3]Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China. [4]Department of pathology, Ningbo Clinical Pathology Diagnosis Center, Ningbo City, Zhejiang Province, 315211, China. [5]Department of Public Research Platform, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China. [6]Department of Rehabilitation, West Kyushu University, Japan. [7]Department of Urology, Kyung Hee University, South Korea. [8]Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

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关键词： SKA3 pan cancer bibliometrics bioinformatic analysis cell proliferation

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Spindle and kinetochore-associated complex subunit 3 (SKA3) is a microtubule-binding subcomplex of the outer kinetochore which plays a vital role in proper chromosomal segregation and cell division. Recently, SKA3 have been demonstrated its oncogenic role of tumorigenesis and development in cancers. In this review, we comprehensively deciphered SKA3 in human cancer from various aspects, including bibliometrics, pan-cancer analysis and narrative summary. We also provided top 10 predicted drugs targeting SKA3. We proposed that SKA3 was a potential target and brought new therapeutic opportunities for cancer patients.Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.

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大类 | 2 区医学

小类 | 2 区外科

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Q1 SURGERY

影响因子： 12.5 最新[2023版] 8.9 最新五年平均 12.5 出版当年[2023版] 0 出版当年五年平均 12.5 出版前一年[2023版]

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第一作者机构： [1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China. [2]Department of Rehabilitation, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, P.R. China.

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