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The roles of tissue resident macrophages in health and cancer

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机构： [1]School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China. [2]Department of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China. [3]School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. [4]Guixi Community Health Center of the Chengdu High-Tech Zone, Chengdu, China.

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关键词： Tissue resident macrophages Bone-marrow derived macrophages Monocytes Homeostasis Cancer

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As integral components of the immune microenvironment, tissue resident macrophages (TRMs) represent a self-renewing and long-lived cell population that plays crucial roles in maintaining homeostasis, promoting tissue remodeling after damage, defending against inflammation and even orchestrating cancer progression. However, the exact functions and roles of TRMs in cancer are not yet well understood. TRMs exhibit either pro-tumorigenic or anti-tumorigenic effects by engaging in phagocytosis and secreting diverse cytokines, chemokines, and growth factors to modulate the adaptive immune system. The life-span, turnover kinetics and monocyte replenishment of TRMs vary among different organs, adding to the complexity and controversial findings in TRMs studies. Considering the complexity of tissue associated macrophage origin, macrophages targeting strategy of each ontogeny should be carefully evaluated. Consequently, acquiring a comprehensive understanding of TRMs' origin, function, homeostasis, characteristics, and their roles in cancer for each specific organ holds significant research value. In this review, we aim to provide an outline of homeostasis and characteristics of resident macrophages in the lung, liver, brain, skin and intestinal, as well as their roles in modulating primary and metastatic cancer, which may inform and serve the future design of targeted therapies.© 2024. The Author(s).

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出版当年[2023]版：

大类 | 1 区医学

小类 | 2 区血液学 2 区肿瘤学

最新[2023]版：

大类 | 1 区医学

小类 | 2 区血液学 2 区肿瘤学

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出版当年[2023]版：

Q1 HEMATOLOGY Q1 ONCOLOGY

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Q1 HEMATOLOGY Q1 ONCOLOGY

影响因子： 9.4 最新[2023版] 8.3 最新五年平均 9.4 出版当年[2023版] 0 出版当年五年平均 9.4 出版前一年[2023版]

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第一作者机构： [1]School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

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