机构：[1]Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA[2]Department of Immuno-Oncology, BeckmanResearch Institute, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA[3]Ludwig Center for Cancer Stem Cell Research and Medicine,Stanford University, Stanford, CA 94305, USA[4]Stanford Cancer Institute, Stanford University, Stanford, CA 94305, USA[5]State Key Laboratory of OralDiseases and National Clinical Research Center for Oral Diseases and West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041,China[6]SRI International, Menlo Park, CA 94025, USA[7]Department of Pathology, Stanford University, Stanford, CA 94305, USA
Macrophage-mediated programmed cell removal (PrCR) is a process essential for the clearance of unwanted (damaged, dysfunctional, aged, or harmful) cells. The detection and recognition of appropriate target cells by macrophages is a critical step for successful PrCR, but its molecular mechanisms have not been delineated. Here using the models of tissue turnover, cancer immunosurveillance, and hematopoietic stem cells, we show that unwanted cells such as aging neutrophils and living cancer cells are susceptible to "labeling" by secreted calreticulin (CRT) from macrophages, enabling their clearance through PrCR. Importantly, we identified asialoglycans on the target cells to which CRT binds to regulate PrCR, and the availability of such CRT-binding sites on cancer cells correlated with the prognosis of patients in various malignancies. Our study reveals a general mechanism of target cell recognition by macrophages, which is the key for the removal of unwanted cells by PrCR in physiological and pathophysiological processes.
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出版当年[2018]版：
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最新[2023]版：
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第一作者：
第一作者机构：[1]Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA[2]Department of Immuno-Oncology, BeckmanResearch Institute, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA
通讯作者：
通讯机构：[1]Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA[2]Department of Immuno-Oncology, BeckmanResearch Institute, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA[3]Ludwig Center for Cancer Stem Cell Research and Medicine,Stanford University, Stanford, CA 94305, USA[4]Stanford Cancer Institute, Stanford University, Stanford, CA 94305, USA[7]Department of Pathology, Stanford University, Stanford, CA 94305, USA
推荐引用方式(GB/T 7714)：
Mingye Feng,Kristopher D. Marjon,Fangfang Zhu,et al.Programmed cell removal by calreticulin in tissue homeostasis and cancer.[J].Nature communications.2018,9(1):3194.doi:10.1038/s41467-018-05211-7.
APA：
Mingye Feng,Kristopher D. Marjon,Fangfang Zhu,Rachel Weissman-Tsukamoto,Aaron Levett...&Irving L. Weissman.(2018).Programmed cell removal by calreticulin in tissue homeostasis and cancer..Nature communications,9,(1)
MLA：
Mingye Feng,et al."Programmed cell removal by calreticulin in tissue homeostasis and cancer.".Nature communications 9..1(2018):3194
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