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Establishment of bladder cancer spheroids and cultured in microfluidic platform for predicting drug response

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资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Xiong Qiao[1,2] ; Liu Ting[3] ; Ying Yidie[2] ; Yu Xiaowen[4] ; Wang Ziwei[2] ; Gao Hongliang[2] ; Lin Tianhai[1] ; Fan Weihua[3] ; Zhang Zhensheng[2] ; Wei Qiang[1] ; Ge Yuqing[3,*1] ; Zeng Shuxiong[2,*2] ; Xu Chuanliang[2,*2] ;
机构： [1]Department of Urology Institute of Urology, West China Hospital, Sichuan University Chengdu P. R. China. [2]Department of Urology Changhai Hospital, Naval Medical University Shanghai P. R. China. [3]State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences Shanghai P. R. China. [4]Department of Geriatrics Changhai Hospital, Naval Medical University Shanghai P. R. China.
出处：
DOI： 10.1002/btm2.10624
ISSN：

关键词： bladder cancer chemotherapy sensitivity microfluidic chip personalized treatment tumor spheroid

摘要：
Cisplatin-containing combination chemotherapy has been used as the standard treatment for bladder cancer patients at advanced stage. However, nearly 50% of patients are nonresponders. To guide the selection of more effective chemotherapeutic agents, a bladder cancer spheroids microfluidic drug sensitivity analysis system was established in this study. Bladder cancer spheroids were established and successfully cultured in a customized microfluidic device to assess their response to different chemotherapeutic agents. The in vitro drug sensitivity results were also compared to patient-derived xenograft (PDX) models and clinical responses of patients. As a result, bladder cancer spheroids faithfully recapitulate the histopathological and genetic features of their corresponding parental tumors. Furthermore, the in vitro drug sensitivity outcomes of spheroids (n = 8) demonstrated a high level of correlation with the PDX (n = 2) and clinical response in patients (n = 2). Our study highlights the potential of combining bladder cancer spheroids and microfluidic devices as an efficient and accurate platform for personalized selection of chemotherapeutic agents.© 2023 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers.

基金：
Discipline Development Plan of Changhai Hospital, Grant/Award Number: 2019YXK041; National Key R&D Program of China, Grant/Award Number: 2022YFA1104703; National Natural Science Foundation of China, Grant/Award Numbers: 81972391, 82172871, 82272950; Qihang program of Second Military Medical University, Grant/Award Number: 2021; Science and Technology Commission of Shanghai Municipality, Grant/Award Numbers: 20Y11904800, 22140903700, 23XTCX00700; Shanghai Municipal Health Commission, Grant/Award Number: 2022YQ010
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 医学
小类 | 2 区 工程：生物医学
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 工程：生物医学
JCR分区：
出版当年[2023]版：
Q1 ENGINEERING, BIOMEDICAL
最新[2023]版：
Q1 ENGINEERING, BIOMEDICAL

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2023版]

第一作者：
第一作者机构： [1]Department of Urology Institute of Urology, West China Hospital, Sichuan University Chengdu P. R. China. [2]Department of Urology Changhai Hospital, Naval Medical University Shanghai P. R. China.
共同第一作者：
通讯作者：
通讯机构： [2]Department of Urology Changhai Hospital, Naval Medical University Shanghai P. R. China. [3]State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences Shanghai P. R. China. [*1]Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Science, Shanghai 200050, China [*2]Department of Urology, Changhai Hospital, Naval Medical University, Shanghai 200433, China
推荐引用方式(GB/T 7714)：
Xiong Qiao,Liu Ting,Ying Yidie,et al.Establishment of bladder cancer spheroids and cultured in microfluidic platform for predicting drug response[J].BIOENGINEERING & TRANSLATIONAL MEDICINE.2024,9(2):e10624.doi:10.1002/btm2.10624.
APA：
Xiong Qiao,Liu Ting,Ying Yidie,Yu Xiaowen,Wang Ziwei...&Xu Chuanliang.(2024).Establishment of bladder cancer spheroids and cultured in microfluidic platform for predicting drug response.BIOENGINEERING & TRANSLATIONAL MEDICINE,9,(2)
MLA：
Xiong Qiao,et al."Establishment of bladder cancer spheroids and cultured in microfluidic platform for predicting drug response".BIOENGINEERING & TRANSLATIONAL MEDICINE 9..2(2024):e10624

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