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Sarcoidosis or Tuberculosis: Should Corticosteroids Be Used?

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机构： [1]Department of Nephrology, Chengdu Seventh People's Hospital (Affiliated Cancer Hospital of Chengdu Medical College), Chengdu, CHN. [2]Department of Nephrology, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, CHN. [3]Department of Nephrology, Zhongjiang County People's Hospital, Deyang, CHN.

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关键词： tuberculosis sarcoidosis interferon-gamma release assays immune responses corticosteroids

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Sarcoidosis shows high similarity with tuberculosis in clinical manifestations and imaging features. It is rarely reported whether sarcoidosis patients with suspected latent tuberculosis can be treated safely with immunosuppressive therapy. We reported on a 54-year-old man who presented with enlarged lymph nodes persisting for decades, accompanied by renal impairment and refractory hypercalcemia. The patient was diagnosed with sarcoidosis and suspected latent tuberculosis (as suggested by a positive tuberculin test and tuberculosis interferon-gamma release assays) and received prednisone under follow-up. The patient showed significant amelioration in hypercalcemia and shrinkage of lymph nodes, without evidence of developing active tuberculosis. For sarcoidosis patients with suspected latent tuberculosis, immunosuppressive agents can be utilized safely based on close monitoring. Further efforts are required to reveal whether sarcoidosis and tuberculosis can trigger similar immune responses and what the clinical implications are.Copyright © 2023, Shen et al.

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第一作者机构： [1]Department of Nephrology, Chengdu Seventh People's Hospital (Affiliated Cancer Hospital of Chengdu Medical College), Chengdu, CHN. [2]Department of Nephrology, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, CHN.

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