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A CuS@g-C3N4 heterojunction endows scaffold with synergetic antibacterial effect

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机构： [1]Institute of Bioadditive Manufacturing, Jiangxi University of Science and Technology, Nanchang 330013, China [2]School of Materials Science and Engineering, Xihua University, Chengdu, Sichuan 610039, China [3]NHC Key Laboratory of Carcinogenesis of Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, Hunan 410013, China [4]The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China [5]Faculty of Materials Metallurgy and Chemistry, Jiangxi University of Science and Technology, Ganzhou 341000, China [6]School of Mechanical and Electrical Engineering, Jiangxi University of Science and Technology, Ganzhou 341000, China [7]State Key Laboratory of Precision Manufacturing for Extreme Service Performance, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China h College of Mechanical Engineering, Xinjiang University, Urumqi 830017, China

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关键词： Photodynamic Photothermal Antibacterial Graphite carbon nitride Copper sulfide

摘要：

Graphitic carbon nitride (g-C3N4) had aroused tremendous attention in photodynamic antibacterial therapy due to its excellent energy band structure and appealing optical performance. Nevertheless, the superfast electron-hole recombination and dense biofilm formation abated its photodynamic antibacterial effect. To this end, a nanoheterojunction was synthesized via in-situ growing copper sulfide (CuS) on g-C3N4 (CuS@g-C3N4). On the one hand, CuS could form Fermi level difference with g-C3N4 to accelerate carrier transfer and thus facilitate electron-hole separation. On the other hand, CuS could respond near-infrared light to generate localized thermal to disrupt biofilm. Then the CuS@g-C3N4 nanoparticle was introduced into the poly-l-lactide (PLLA) scaffold. The photoelectrochemistry results demonstrated that the electron-hole separation efficiency was apparently enhanced and thereby brought an approximate sevenfold increase in reactive oxygen species (ROS) production. The thermal imaging indicated that the scaffold possesses a superior photothermal effect, which effectively eradicated the biofilm by disrupting its extracellular DNA and thereby facilitated to the entry of ROS. The entered ROS could effectively kill the bacteria by causing protein, K+, and nucleic acid leakage and glutathione consumption. As a consequence, the scaffold displayed an antibacterial rate of 97.2% and 98.5% against E. coli and S. aureus, respectively.Copyright © 2023 Elsevier B.V. All rights reserved.

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出版当年[2023]版：

大类 | 2 区

医学

小类 | 1 区生物物理 2 区物理化学 3 区材料科学：生物材料

最新[2023]版：

大类 | 2 区

医学

小类 | 1 区生物物理 2 区物理化学 3 区材料科学：生物材料

第一作者：

第一作者机构： [1]Institute of Bioadditive Manufacturing, Jiangxi University of Science and Technology, Nanchang 330013, China

通讯作者：

通讯机构： [1]Institute of Bioadditive Manufacturing, Jiangxi University of Science and Technology, Nanchang 330013, China [7]State Key Laboratory of Precision Manufacturing for Extreme Service Performance, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China h College of Mechanical Engineering, Xinjiang University, Urumqi 830017, China [*1]Institute of Bioadditive Manufacturing, Jiangxi University of Science and Technology, Nanchang 330013, China.

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A CuS@g-C3N4 heterojunction endows scaffold with synergetic antibacterial effect

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