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A generalizable new figure of merit for dose optimization in dual energy cone beam CT scanning protocols

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机构： [1]Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing, 100142, China [2]Department of Physics and Astronomy, University of British Columbia, 325‑6224 Agricultural Road, Vancouver, BC V6T1Z1, Canada [3]Department of Radiotherapy Physics & Technology, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, China [4]Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06510, USA [5]School of Electronics, Peking University, Beijing, 100871, China [6]Shenzhen Bay Laboratory, Shenzhen, 518118, China

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关键词： Dual-energy imaging Cone beam CT Scanning optimization Image Wisely Image Gently

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This study proposes and evaluates a new figure of merit (FOMn) for dose¬ optimization of Dual-energy CBCT (DE-CBCT) scanning protocols based on size-dependent modeling of radiation dose and multi-scale image quality.Approach: FOMn was defined using Z-score normalization and was proportional to the dose efficiency providing better multi-scale image quality, including comprehensive contrast-to-noise ratio (CCNR) and electron density (CED) for CatPhan604 inserts of various materials. Acrylic annuluses were combined with CatPhan604 to create four phantom sizes (diameters of the long axis are 200 mm, 270 mm, 350 mm, and 380 mm, respectively). DE-CBCT was decomposed using image-domain iterative methods based on Varian kV-CBCT images acquired using 25 protocols (100 kVp and 140 kVp combined with 5 tube currents).Main results: The accuracy of CED was approximately 1% for all protocols, but degraded monotonically with the increased phantom sizes. Combinations of lower voltage + higher current and higher voltage + lower current were optimal protocols balancing CCNR and dose. The most dose-efficient protocols for CED and CCNR were inconsistent, underlining the necessity of including multi-scale image quality in the evaluation and optimization of DE-CBCT. Pediatric and adult anthropomorphic phantom tests confirmed dose-efficiency of FOMn-recommended protocols.Significance: FOMn is a comprehensive metric that collectively evaluates radiation dose and multi-scale image quality for DE-CBCT. The models and data can also serve as lookup tables, suggesting personalized dose-efficient protocols for specific clinical imaging purposes.© 2023 Institute of Physics and Engineering in Medicine.

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出版当年[2023]版：

大类 | 3 区医学

小类 | 3 区工程：生物医学 3 区核医学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区工程：生物医学 3 区核医学

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第一作者机构： [1]Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing, 100142, China [2]Department of Physics and Astronomy, University of British Columbia, 325‑6224 Agricultural Road, Vancouver, BC V6T1Z1, Canada

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