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Sarcopenia prevalence in patients with cancer and association with adverse prognosis: A nationwide survey on common cancers

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机构: [1]Colorectal Cancer Center/Department of Gastrointestinal Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. [2]College of Public Health, Zhengzhou University, Zhengzhou, China. [3]Department of Medical Oncology, Fujian Provincial Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, China. [4]Department of Nutrition, The First Affiliated Hospital of Kunming Medical University, Kunming, China. [5]Department of Oncology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China. [6]General Surgery Department, The Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China. [7]Comprehensive Oncology Department, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. [8]Department of Radiotherapy, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. [9]Department of Nutrition, the First Affiliated Hospital of Hebei Medical University, Shijiazhuang, China. [10]Department of Gastrointestinal Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. [11]Cancer Center, the First Hospital, Jilin University, Changchun, China. [12]Department of Nutrition, Daping Hospital, Army Medical University, Chongqing, China. [13]Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University/ Key Laboratory of Cancer FSMP for State Market Regulation, Beijing, China. Electronic address: shihp@ccmu.edu.cn.
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关键词: Sarcopenia Cancer Aging Muscle Morality

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Although previous studies have implicated the negative outcomes of sarcopenia, evidence is limited to one or a few types of cancer. The aim of this study was to evaluate the distribution and influencing factors of sarcopenia, and explore the relationship between sarcopenia and cancer prognosis in a large oncological population.This observational cohort study included patients diagnosed with malignant cancer between May 2011 and January 2019. Hematologic and anthropometric parameters were collected prospectively. Low skeletal muscle mass and radiodensity were diagnosed using clinical indicators, according to the two prediction models. The importance of potential risk factors for sarcopenia was estimated by subtracting the predicted degrees of freedom from the partial χ2 statistic. Hazard rates of death were calculated using the hazard function and Cox regression analyses.We included 13 761 patients with cancer; the prevalence of sarcopenia was 33%. The median age was 58 y and 7135 patients (52%) were men. Patients with sarcopenia had a worse nutritional status and quality of life than those without sarcopenia. Age was the most important risk factor for sarcopenia compared with body mass index or TNM stage. Additionally, patients with sarcopenia had a significantly higher and earlier peak risk for mortality. After adjusting for baseline characteristics, sarcopenia was independently associated with mortality in the research population (hazard ratio, 1.429; P < 0.001) and most cancer types.Age is the most important risk factor for sarcopenia even in patients with cancer. Sarcopenia is strongly associated with a poor quality of life and reduced overall survival.Copyright © 2023 Elsevier Inc. All rights reserved.

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大类 | 3 区 医学
小类 | 3 区 营养学
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大类 | 3 区 医学
小类 | 3 区 营养学
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Q2 NUTRITION & DIETETICS
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Q2 NUTRITION & DIETETICS

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第一作者机构: [1]Colorectal Cancer Center/Department of Gastrointestinal Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
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