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Reference Values for Paravertebral Muscle Size and Myosteatosis in Chinese Adults, a Nationwide Multicenter Study

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机构: [1]Department of Spine Surgery, Beijing Jishuitan Hospital, National Centre for Orthopaedics, Capital Medical University, Beijing, China; JST sarcopenia Research Centre, National Centre for Orthopaedics, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Beijing, China. [2]Clinical Epidemiology Research Centre, Beijing Jishuitan Hospital, National Centre for Orthopaedics, Capital Medical University, Beijing, China. [3]Department of Radiology, Beijing Jishuitan Hospital, National Centre for Orthopaedics, Capital Medical University, Beijing, China. [4]Department of Spine Surgery, Beijing Jishuitan Hospital, National Centre for Orthopaedics, Capital Medical University, Beijing, China. [5]West China Hospital of Sichuan University, Sichuang Province, China. [6]Qingshan Lake Community Health Service Station, Nanchang, China. [7]BGI-Shenzhen, Beishan Industrial Zone, Shenzhen, Guangdong, China. [8]JST sarcopenia Research Centre, National Centre for Orthopaedics, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Beijing, China. [9]Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands. [10]JST sarcopenia Research Centre, National Centre for Orthopaedics, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Beijing, China; Department of Radiology, Beijing Jishuitan Hospital, National Centre for Orthopaedics, Capital Medical University, Beijing, China. [11]Department of Spine Surgery, Beijing Jishuitan Hospital, National Centre for Orthopaedics, Capital Medical University, Beijing, China; JST sarcopenia Research Centre, National Centre for Orthopaedics, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Beijing, China. Electronic address: drliuyajun@163.com.
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关键词: Sarcopenia Quantitative computed tomography Reference values Paravertebral muscles Aging

摘要:
The paravertebral muscles, characterized by their susceptibility to severe size loss and fat infiltration in old age, lack established reference values for age-related variations in muscle parameters. This study aims to fill this gap by establishing reference values for paravertebral muscles in a Chinese adult population.This cross-sectional study utilized the baseline data from the prospective cohort China Action on Spine and Hip (CASH). A total of 4305 community-dwelling participants aged 21-80 years in China were recruited between 2013 and 2017. Pregnant women, individuals with metal implants, limited mobility or diseases/conditions (spinal tumor, infection, etc.) affecting lumbar vertebra were excluded from the study. Psoas and paraspinal muscles were measured in quantitative computed tomography (QCT) images at the L3 and L5 levels using Osirix software. Age-related reference values for muscle area, density, and fat fraction were constructed as percentile charts using the lambda-mu-sigma (LMS) method.The paravertebral muscles exhibited an age-related decline in muscle area and density, coupled with an increase in muscle fat fraction. Between the ages of 25 and 75, the reductions in psoas and paraspinal muscle cross-sectional area at the L3 level were - 0.47%/yr and - 0.53%/yr in men, and - 0.19%/yr and - 0.23%/yr in women, respectively. Notably, accelerated muscle loss was observed during menopause and postmenopause in women (45-75 years) and intermittently during middle and old age in men (35-55 and 60-75 years). Besides, the age-related decreases in PSMA, PMA, and PSMD and the increases in PSMFF were more pronounced in L5 than in L3 CONCLUSION: This study shows distinct patterns of accelerated muscle loss were identified in menopausal and postmenopausal women and in middle-aged and old men. The findings contribute valuable information for future investigations on paravertebral muscle loss and myosteatosis.Copyright © 2024. Published by Elsevier Inc.

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大类 | 2 区 医学
小类 | 2 区 核医学
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大类 | 2 区 医学
小类 | 2 区 核医学
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第一作者机构: [1]Department of Spine Surgery, Beijing Jishuitan Hospital, National Centre for Orthopaedics, Capital Medical University, Beijing, China; JST sarcopenia Research Centre, National Centre for Orthopaedics, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Beijing, China. [2]Clinical Epidemiology Research Centre, Beijing Jishuitan Hospital, National Centre for Orthopaedics, Capital Medical University, Beijing, China.
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通讯机构: [1]Department of Spine Surgery, Beijing Jishuitan Hospital, National Centre for Orthopaedics, Capital Medical University, Beijing, China; JST sarcopenia Research Centre, National Centre for Orthopaedics, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Beijing, China. [2]Clinical Epidemiology Research Centre, Beijing Jishuitan Hospital, National Centre for Orthopaedics, Capital Medical University, Beijing, China.
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