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KHSRP combines transcriptional and posttranscriptional mechanisms to regulate monocytic differentiation

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收录情况： ◇ 卓越：高起点新刊 ◇ ESCI ◇ 中华系列

作者：
Xu Jiayue[1,2] * ; Wang Dongsheng[3] * ; Ma Hongliu[4] * ; Zhai Xueying[1,2] ; Huo Yue[1,2] ; Ren Yue[1,2] ; Li Weiqian[1,2] ; Chang Le[1,2] ; Lu Dongxu[1,2] ; Guo Yuehong[1,2] ; Si Yanmin[1,2] ; Gao Yufeng[1,2] ; Wang Xiaoshuang[1,2] ; Ma Yanni[1,2] ; Wang Fang[1,2,*1] ; Yu Jia[1,2,5,*1] ;
机构： [1]State Key Laboratory of Medical Molecular Biology, Haihe Laboratory of Cell Ecosystem, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China. [2]Key Laboratory of RNA and Hematopoietic Regulation, Chinese Academy of Medical Sciences, Beijing 100005, China. [3]Department of Clinical Laboratory, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China. [4]Department of Gynecology, Dian Jiang People's Hospital of Chong Qing, Chongqing 408300, China. [5]Medical Epigenetic Research Center, Chinese Academy of Medical Sciences, Beijing 100005, China.
出处：
DOI： 10.1097/BS9.0000000000000122
ISSN：

关键词： KHSRP Monocytic differentiation RNA-binding proteins Transcriptional regulation

摘要：
RNA-binding proteins (RBPs) are widely involved in the transcriptional and posttranscriptional regulation of multiple biological processes. The transcriptional regulatory ability of RBPs was indicated by the identification of chromatin-enriched RBPs (Che-RBPs). One of these proteins, KH-type splicing regulatory protein (KHSRP), is a multifunctional RBP that has been implicated in mRNA decay, alternative splicing, and miRNA biogenesis and plays an essential role in myeloid differentiation by facilitating the maturation of miR-129. In this study, we revealed that KHSRP regulates monocytic differentiation by regulating gene transcription and RNA splicing. KHSRP-occupied specific genomic sites in promoter and enhancer regions to regulate the expression of several hematopoietic genes through transcriptional activation and bound to pre-mRNA intronic regions to modulate alternative splicing during monocytic differentiation. Of note, KHSRP had co-regulatory effects at both the transcriptional and posttranscriptional levels on MOGOH and ADARB1. Taken together, our analyses revealed the dual DNA- and RNA-binding activities of KHSRP and have provided a paradigm to guide the analysis of other functional Che-RBPs in different biological systems.Copyright © 2022 The Authors. Published by Wolters Kluwer Health Inc., on behalf of the Chinese Medical Association (CMA) and Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College (IHCAMS).

基金：
National Key Research and Development Program of China (2019YFA0801800, 2021YFA1102400, 2019YFA0802600 and 2021YFA0805703) ; the National Natural Science Foundation of China (81530007, 31900072, 31725013, 82022001, 82122005, 81970103 and 81970101); CAMS Innovation Fund for Medical Sciences [2021-I2M-1-019 and 2021-I2M-1-040].
语种：
外文
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中科院(CAS)分区：
出版当年[2022]版：
无
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 血液学
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出版当年[2022]版：
无
最新[2023]版：
Q3 HEMATOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]State Key Laboratory of Medical Molecular Biology, Haihe Laboratory of Cell Ecosystem, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China. [2]Key Laboratory of RNA and Hematopoietic Regulation, Chinese Academy of Medical Sciences, Beijing 100005, China.
共同第一作者：
通讯作者：
通讯机构： [1]State Key Laboratory of Medical Molecular Biology, Haihe Laboratory of Cell Ecosystem, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China. [2]Key Laboratory of RNA and Hematopoietic Regulation, Chinese Academy of Medical Sciences, Beijing 100005, China. [5]Medical Epigenetic Research Center, Chinese Academy of Medical Sciences, Beijing 100005, China. [*1]State Key Laboratory of Medical Molecular Biology, Haihe laboratory of Cell Ecosystem, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China.
推荐引用方式(GB/T 7714)：
Xu Jiayue,Wang Dongsheng,Ma Hongliu,et al.KHSRP combines transcriptional and posttranscriptional mechanisms to regulate monocytic differentiation[J].BLOOD SCIENCE.2022,4(3):103-115.doi:10.1097/BS9.0000000000000122.
APA：
Xu Jiayue,Wang Dongsheng,Ma Hongliu,Zhai Xueying,Huo Yue...&Yu Jia.(2022).KHSRP combines transcriptional and posttranscriptional mechanisms to regulate monocytic differentiation.BLOOD SCIENCE,4,(3)
MLA：
Xu Jiayue,et al."KHSRP combines transcriptional and posttranscriptional mechanisms to regulate monocytic differentiation".BLOOD SCIENCE 4..3(2022):103-115

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