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PRMT1 promotes the proliferation and metastasis of gastric cancer cells by recruiting MLXIP for the transcriptional activation of the β-catenin pathway

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收录情况： ◇ CSCD-C ◇ 卓越：高起点新刊

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机构： [1]State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China. [2]Cancer Center, Medical Research Institute, Southwest University, Chongqing 400716, China. [3]Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, 25 Taiping Street, Jiangyang District, Luzhou, Sichuan 646000, China. [4]Jinfeng Laboratory, Chongqing 401329, China.

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关键词： b-catenin signaling pathway Gastric cancer PRMT1 Transcriptional regulation Ubiquitination

摘要：

Protein arginine methyltransferase 1 (PRMT1), a type I PRMT, is overexpressed in gastric cancer (GC) cells. To elucidate the function of PRMT1 in GC, PRMT1 expression in HGC-27 and MKN-45 cells was knocked down by short hairpin RNA (shRNA) or inhibited by PRMT1 inhibitors (AMI-1 or DCLX069), which resulted in inhibition of GC cell proliferation, migration, invasion, and tumorigenesis in vitro and in vivo. MLX-interacting protein (MLXIP) and Kinectin 1 (KTN1) were identified as PRMT1-binding proteins. PRMT1 recruited MLXIP to the promoter of β-catenin, which induced β-catenin transcription and activated the β-catenin signaling pathway, promoting GC cell migration and metastasis. Furthermore, KTN1 inhibited the K48-linked ubiquitination of PRMT1 by decreasing the interaction between TRIM48 and PRMT1. Collectively, our findings reveal a mechanism by which PRMT1 promotes cell proliferation and metastasis mediated by the β-catenin signaling pathway.© 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

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出版当年[2023]版：

大类 | 2 区医学

小类 | 2 区生化与分子生物学 2 区遗传学

最新[2023]版：

大类 | 2 区医学

小类 | 2 区生化与分子生物学 2 区遗传学

第一作者：

第一作者机构： [1]State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China. [2]Cancer Center, Medical Research Institute, Southwest University, Chongqing 400716, China.

通讯作者：

通讯机构： [1]State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China. [2]Cancer Center, Medical Research Institute, Southwest University, Chongqing 400716, China. [4]Jinfeng Laboratory, Chongqing 401329, China.

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PRMT1 promotes the proliferation and metastasis of gastric cancer cells by recruiting MLXIP for the transcriptional activation of the β-catenin pathway

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